{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:12Z","timestamp":1791820932035,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570322\u00a0and 81100141"],"award-info":[{"award-number":["81570322\u00a0and 81100141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin (IL)\u201015 is a recently identified cytokine, which belongs to the interleukin\u20102(IL\u20102) family, and plays an important role in innate and adaptive immunoreaction. Given the fact that the structure of IL\u201015 is partially similar to IL\u20102, they share some common biological effects, including immunoregulation. IL\u20102 was proven to protect cardiac function in mouse myocardial infarction models. Cardiovascular diseases (CVDs) dominate the cause of mortality worldwide. Besides atherosclerosis, inflammation is also widely involved in the pathogenesis of many CVDs including hypertension, heart failure (HF) and aneurysm. IL\u201015, as a pro\u2010inflammatory cytokine, is up\u2010regulated in some cardiovascular diseases, such as myocardial infarction and atherosclerosis. The current understanding of IL\u201015, including its signal pathway and cellular function, was described. Furthermore, IL\u201015 has a protective effect in myocardial infarction and myocarditis by decreasing cardiomyocyte death and improving heart function. The inhibited effect of IL\u201015 in ductus arteriosus (DA) should be focused on. IL\u201015 promoted atherogenesis. IL\u201015 may be a good target in treatment of cardiovascular diabetology. Finally, future research direction of IL\u201015 deserves attention. Since IL\u201015 plays several roles in CVDs, understanding the role of the IL\u201015\/IL\u201015R system may provide a scientific basis for the development of new approaches that use IL\u201015 for the treatment of CVDs.<\/jats:p>","DOI":"10.1111\/jcmm.15296","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T06:41:04Z","timestamp":1589438464000},"page":"7094-7101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Role of interleukin\u201015 in cardiovascular diseases"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-018X","authenticated-orcid":false,"given":"Lei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Cardiovascular Key Lab of Zhejiang Province Hangzhou 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