{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:46:21Z","timestamp":1780487181819,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772663"],"award-info":[{"award-number":["81772663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972341"],"award-info":[{"award-number":["81972341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with relapsed\/refractory Burkitt's lymphoma (BL) have a dismal prognosis. Current research efforts aim to increase cure rates by identifying high\u2010risk patients in need of more intensive or novel therapy. The 8q24 chromosomal translocation of the c\u2010Myc gene, a main molecular marker of BL, is related to the metabolism by regulating phosphoribosyl pyrophosphate synthetase 2 (PRPS2). In our study, BL showed significant resistance to thiopurines. PRPS2 homologous isoenzyme, PRPS1, was demonstrated to play the main role in thiopurine resistance. c\u2010Myc did not have direct effects on thiopurine resistance in BL for only driving PRPS2. PRPS1 wild type (WT) showed different resistance to 6\u2010mercaptopurine (6\u2010mp) in different metabolic cells because it could be inhibited by adenosine diphosphate or guanosine diphosphate negative feedback. PRPS1 A190T mutant could dramatically increase thiopurine resistance in BL. The interim analysis of the Treatment Regimen for Children or Adolescent with mature B cell non\u2010Hodgkin's lymphoma in China (CCCG\u2010B\u2010NHL\u20102015 study) confirms the value of high\u2010dose methotrexate (MTX) and cytarabine (ARA\u2010C) in high\u2010risk paediatric patients with BL. However, there remains a subgroup of patients with lactate dehydrogenase higher than four times of the normal value (4N) for whom novel treatments are needed. Notably, we found that the combination of thiopurines and the phosphoribosylglycinamide formyltransferase (GART) inhibitor lometrexol could serve as a therapeutic strategy to overcome thiopurine resistance in BL.<\/jats:p>","DOI":"10.1111\/jcmm.15322","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T09:24:00Z","timestamp":1589189040000},"page":"6704-6715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Molecular mechanism of c\u2010Myc and PRPS1\/2 against thiopurine resistance in Burkitt's lymphoma"],"prefix":"10.1111","volume":"24","author":[{"given":"Ting","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Xv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejia","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1055-5029","authenticated-orcid":false,"given":"Yanxin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Department of Hematology &amp; Oncology Shanghai Children\u2019s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2010.08.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710366114"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14604"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.052"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0712"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90043-T"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120304"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3840"},{"issue":"01","key":"e_1_2_8_11_1","first-page":"87","article-title":"Non\u2010Hodgkin lymphoma in children and adolescents","volume":"225","author":"Reiter A","year":"2013","journal-title":"Klin Padiatr"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.06.019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061189"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"100","article-title":"A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60 and glyceraldehyde\u20103\u2010phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues","volume":"63","author":"Kynetski EY","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5827"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204088"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002722"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6390"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152241"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(94)00017-W"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118267"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2008.09.014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.1.123"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3370"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0973"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.15322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:13:35Z","timestamp":1694002415000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/jcmm.15322"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15322","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,11]]},"assertion":[{"value":"2019-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}