{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T07:13:51Z","timestamp":1778397231221,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201012\u20100440"],"award-info":[{"award-number":["NCET\u201012\u20100440"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973175\/C1701"],"award-info":[{"award-number":["30973175\/C1701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201060\/C0709"],"award-info":[{"award-number":["31201060\/C0709"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172490\/H1621"],"award-info":[{"award-number":["81172490\/H1621"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772793\/H1621"],"award-info":[{"award-number":["81772793\/H1621"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Long non\u2010coding RNAs (lncRNAs) are key regulators or a range of diseases and chronic conditions such as cancers, but how they function in the context of ovarian cancer (OC) is poorly understood. The Coding\u2010Potential Assessment Tool was used to assess the likely protein\u2010coding potential of SNHG7. SNHG7 expression was elevated in ovarian tumour tissues measured by qRT\u2010PCR. The online database JASPAR was used to predict the transcription factors binding to SNHG7. Twenty\u2010four\u2010well Transwell plates were used for invasion assays. RNA immunoprecipitation was performed to determine RNA\u2010protein associations. EdU assay was introduced to detect cell proliferation. Chromatin immunoprecipitation was performed to confirm the directly interaction between DNA and protein. We discovered that in the context of OC there is a significant up\u2010regulation of the lncRNA SNHG7. Knocking down this lncRNA disrupted both OC cell invasion and proliferation, while its overexpression had the opposite effect. SP1 binding sites were present in the SNHG7 promoter, and chromatin immunoprecipitation (ChIP) confirmed direct SP1 binding to this region, activating SNHG7 transcription. We found that at a mechanistic level in OC cells, KLF2 is a probable SNHG7 target, as we found that SHNCCC16 directly interacts with EZH2 and thus represses KLF2 expression. In summary, this research demonstrates that lncRNA SNHG7 is an SP1\u2010activated molecule that contributes to OC progression by providing a scaffold whereby EZH2 can repress KLF2 expression.<\/jats:p>","DOI":"10.1111\/jcmm.15373","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T07:32:53Z","timestamp":1589787173000},"page":"7479-7489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Long non\u2010coding RNA SNGH7 Is activated by SP1 and exerts oncogenic properties by interacting with EZH2 in ovarian cancer"],"prefix":"10.1111","volume":"24","author":[{"given":"Zhuanli","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Maxillofacial Surgery First Affiliated Hospital of Xi'an Jiao Tong University Xi\u2019an 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