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At present, the treatment of ONFH is still a global medical problem. We aim to explore the role of bone mesenchymal stem cells (BMSCs)\u2010derived and siRNAs\u2010encapsulated exosomes (siRNAs\u2010encapsulated BMSCexos) in ONFH. We first isolated BMSCexos and screened siRNAs of 6 ONFH\u2010related genes for siRNAs\u2010encapsulated BMSCexo. The expression of these 6 ONFH\u2010related genes in dexamethasone (DXM)\u2010treated MC3T3\u2010E1 cell, cell model of ONFH, was detected by RT\u2010qPCR and Western blot analysis. And then, we performed CCK\u20108 assay, angiogenesis assay and HE staining analysis to test the promotion role of the siRNAs\u2010encapsulated BMSCexo for angiogenesis during ONFH repair. The results suggest that the obtained particles were BMSCexos. The screened effective siRNAs could effectively knock down their expression in VECs. Moreover, siRNAs\u2010encapsulated BMSCexo could effectively knock down the expression of these genes in VECs. In addition, siRNAs\u2010encapsulated BMSCexo promote angiogenesis during ONFH repair. In conclusion, we found siRNAs\u2010encapsulated BMSCexos could promote ONFH repair by angiogenesis, and indicated exosome as the new siRNA carrier is of great significance to improve the efficiency of RNAi.<\/jats:p>","DOI":"10.1111\/jcmm.15395","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T10:34:09Z","timestamp":1596537249000},"page":"9605-9612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mesenchymal stem cells\u2010derived and siRNAs\u2010encapsulated exosomes inhibit osteonecrosis of the femoral head"],"prefix":"10.1111","volume":"24","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of 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