{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:41:54Z","timestamp":1790365314963,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["EQU201903007868"],"award-info":[{"award-number":["EQU201903007868"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The transcription factor peroxisome proliferator\u2010activated receptor gamma (PPARG) is essential for placental development, and alterations in its expression and\/or activity are associated with human placental pathologies such as pre\u2010eclampsia or IUGR. However, the molecular regulation of PPARG in cytotrophoblast differentiation and in the underlying mesenchyme remains poorly understood. Our main goal was to study the impact of mutations in the ligand\u2010binding domain (LBD) of the\n                    <jats:italic>PPARG<\/jats:italic>\n                    gene on cytotrophoblast fusion (PPARG\n                    <jats:sup>E352Q<\/jats:sup>\n                    ) and on fibroblast cell migration (PPARG\n                    <jats:sup>R262G<\/jats:sup>\n                    \/PPARG\n                    <jats:sup>L319X<\/jats:sup>\n                    ). Our results showed that, compared to cells with reconstituted PPARG\n                    <jats:sup>WT<\/jats:sup>\n                    , transfection with PPARG\n                    <jats:sup>E352Q<\/jats:sup>\n                    led to significantly lower PPARG activity and lower restoration of trophoblast fusion. Likewise, compared to PPARG\n                    <jats:sup>WT<\/jats:sup>\n                    fibroblasts, PPARG\n                    <jats:sup>R262G<\/jats:sup>\n                    \/PPARG\n                    <jats:sup>L319X<\/jats:sup>\n                    fibroblasts demonstrated significantly inhibited cell migration. In conclusion, we report that single missense or nonsense mutations in the LBD of PPARG significantly inhibit cell fusion and migration processes.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15401","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T02:23:23Z","timestamp":1591755803000},"page":"7660-7669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Peroxisome proliferator\u2010activated receptor gamma\u2010ligand\u2010binding domain mutations associated with familial partial lipodystrophy type 3 disrupt human trophoblast fusion and fibroblast migration"],"prefix":"10.1111","volume":"24","author":[{"given":"Hussein","family":"Shoaito","sequence":"first","affiliation":[{"name":"INSERM UMR\u2010S1139 (3PHM) Universit\u00e9 de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Chauveau","sequence":"additional","affiliation":[{"name":"INSERM UMR\u2010S1139 (3PHM) Universit\u00e9 de Paris Paris France"},{"name":"Laboratoire ICARE Biop\u00f4le Clermont\u2010Limagne Saint\u2010Beauzire France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Gosseaume","sequence":"additional","affiliation":[{"name":"Inserm UMR\u2010S938 Department of Endocrinology, Diabetology and Reproductive Endocrinology Saint\u2010Antoine Research Centre Institute of Cardiometabolism and Nutrition (ICAN) AP\u2010HP Saint\u2010Antoine Hospital National Reference Centre of Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS) Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bourguet","sequence":"additional","affiliation":[{"name":"INSERM CNRS Centre de Biochimie Structurale (CBS) Universit\u00e9 de Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Vigouroux","sequence":"additional","affiliation":[{"name":"Inserm UMR\u2010S938 Department of Endocrinology, Diabetology and Reproductive Endocrinology Saint\u2010Antoine Research Centre Institute of Cardiometabolism and Nutrition (ICAN) AP\u2010HP Saint\u2010Antoine Hospital National Reference Centre of Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS) Sorbonne Universit\u00e9 Paris France"},{"name":"Department of Molecular Biology and Genetics AP\u2010HP, Saint\u2010Antoine Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Vatier","sequence":"additional","affiliation":[{"name":"Inserm UMR\u2010S938 Department of Endocrinology, Diabetology and Reproductive Endocrinology Saint\u2010Antoine Research Centre Institute of Cardiometabolism and Nutrition (ICAN) AP\u2010HP Saint\u2010Antoine Hospital National Reference Centre of Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS) Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Pienkowski","sequence":"additional","affiliation":[{"name":"Endocrinology Unit Reference Centre for Rare Gynecologic Diseases Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fournier","sequence":"additional","affiliation":[{"name":"INSERM UMR\u2010S1139 (3PHM) Universit\u00e9 de Paris Paris France"},{"name":"PremUp Foundation Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6263-4875","authenticated-orcid":false,"given":"S\u00e9verine A.","family":"Degrelle","sequence":"additional","affiliation":[{"name":"INSERM UMR\u2010S1139 (3PHM) Universit\u00e9 de Paris Paris France"},{"name":"PremUp Foundation Paris 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