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This study was aimed to examine the effect of forskolin (FSK), a cyclic adenosine monophosphate (cAMP)\u2010elevating agent, on vascular response to angioplasty wire injury and on atherogenesis in mice. Forskolin treatment reduced neointima formation at 7 and 28\u00a0days after wire injury. Early morphometrics of the injured vessels revealed that FSK treatment enhanced endothelial repair and reduced inflammatory cell infiltration. In vitro treatment of primary aortic cells with FSK, at 3\u2010100\u00a0\u03bcmol\/L, increased endothelial cell proliferation, whereas FSK, at 30\u2010100\u00a0\u03bcmol\/L, inhibited smooth muscle cell proliferation. FSK inhibited lipopolysaccharide\u2010induced leucocyte\u2010endothelial interaction in vitro and in vivo. In a mouse model of atherosclerosis driven by dyslipidaemia and hypertension, FSK administration increased endothelial repair and reduced atherosclerotic plaque formation, without affecting blood pressure, plasma lipids or aortic aneurysms formation. In summary, FSK, at doses relevant to human therapeutic use, protects against neointimal hyperplasia and atherogenesis, and this is attributable to its activities on pro\u2010endothelial repair and anti\u2010inflammation. This study raises a potential of clinical use of FSK as an adjunct therapy to prevent restenosis and atherosclerosis after percutaneous coronary intervention.<\/jats:p>","DOI":"10.1111\/jcmm.15476","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T02:38:45Z","timestamp":1598582325000},"page":"9638-9645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The cyclic adenosine monophosphate elevating medicine, forskolin, reduces neointimal formation and atherogenesis in mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Huifeng","family":"Hao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Department of Integration of Chinese and Western Medicine Key Laboratory of Carcinogenesis and 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