{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:27:52Z","timestamp":1779204472520,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["bs6619026"],"award-info":[{"award-number":["bs6619026"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver fibrosis is a disease caused by long\u2010term damage that is related to a number of factors. The current research on the treatment of liver fibrosis mainly focuses on the activation of hepatic stellate cell, in addition to protecting liver cells. byakangelicin has certain anti\u2010inflammatory ability, but its effect on liver fibrosis is unclear. This study aims to explore whether byakangelicin plays a role in the development of liver fibrosis and to explore its mechanism. We determined that byakangelicin has a certain ability to resist fibrosis and reduce liver cell damage in a model of carbon tetrachloride\u2013induced liver fibrosis in mice. Thereafter, we performed further verification in vitro. The signalling pathways of two important pro\u2010fibrotic cytokines, transforming growth factor\u2010\u03b2 and platelet\u2010derived growth factor, were studied. Results showed that byakangelicin can inhibit related pathways. According to the hepatoprotective effect of byakangelicin observed in animal experiments, we studied the effect of byakangelicin on 4\u2010HNE\u2013induced hepatocyte (HepG2) apoptosis and explored its related pathways. The results showed that byakangelicin could attenuate 4\u2010HNE\u2013induced hepatocyte apoptosis via inhibiting ASK\u20101\/JNK signalling. In conclusion, byakangelicin could improve carbon tetrachloride\u2013induced liver fibrosis and liver injury by inhibiting hepatic stellate cell proliferation and activation and suppressing hepatocyte apoptosis.<\/jats:p>","DOI":"10.1111\/jcmm.15493","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T11:42:47Z","timestamp":1594294967000},"page":"8623-8635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Byakangelicin protects against carbon tetrachloride\u2013induced liver injury and fibrosis in mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaohe","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-6743","authenticated-orcid":false,"given":"Shuaibo","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhun","family":"Bi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiying","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiakun","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruotong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyang","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowei","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Tian Jin First Central Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfeng","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Life Sciences Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-3422","authenticated-orcid":false,"given":"Honggang","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin China"},{"name":"Tianjin Key Laboratory of Molecular Drug Research Tianjin International Joint Academy of Biomedicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374096"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7407.143"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i42.12042"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.8.5.423"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.05.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.82.155"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.38"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13665"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1246-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.10.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.01.036"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7641"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.07.019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm828"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000069036.63405.5C"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21093"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3453926"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2014.03.011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32075"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01069.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39702"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960407a"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2630357"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.065"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2012.07.004"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5268-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_06.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042127"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.069534"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28734"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007293108"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.03.006"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi100517x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.033"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.06.008"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26541"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00148-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260316"},{"issue":"9","key":"e_1_2_7_42_1","first-page":"5998","article-title":"Yu Jin Pulvis inhibits carbon tetrachloride\u2010induced liver fibrosis by blocking the MAPK and PI3K\/Akt signaling pathways","volume":"11","author":"Wu W","year":"2019","journal-title":"Am J Transl Res"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.0179"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2005.pto_06.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5268-0"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-5-9"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.032"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.05.011"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17558"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04658.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.02.011"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0065-y"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(00)00004-2"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00073-9"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.04.007"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.15493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T10:49:34Z","timestamp":1710931774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,9]]},"references-count":54,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/jcmm.15493"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15493","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,9]]},"assertion":[{"value":"2020-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}