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Immunohistochemical analysis revealed that significantly higher expression of Lin28a was observed in the iliac arteries of restenosis plaques than that of atherosclerosis plaques. Immunofluorescence studies showed the colocalization of Lin28a with \u03b1\u2010smooth muscle actin in restenosis plaques, rather than in atherosclerosis plaques, which suggested that Lin28a might be related to the unique behaviour of vascular smooth muscle cells (VSMCs) in restenosis. To further confirm above hypothesis, Lin28a expression was up\u2010regulated by transfection of Lenti\u2010Lin28a and inhibited by Lenti\u2010Lin28a\u2010shRNA transfection in cultured VSMCs, and then the proliferation and migration capability of VSMCs were detected by EdU and Transwell assays, respectively. Results showed that the proliferation and migration of VSMCs were significantly increased in accordance with the up\u2010regulation of Lin28a expression, while above behaviours of VSMCs were significantly suppressed after inhibiting the expression of Lin28a. In conclusion, the up\u2010regulation of Lin28a exerts its modulatory effect on VSMCs\u2019 proliferation and migration, which may play a critical role in contributing to pathological formation of restenosis.<\/jats:p>","DOI":"10.1111\/jcmm.15506","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T08:41:07Z","timestamp":1595666467000},"page":"9682-9691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lin28a up\u2010regulation is associated with the formation of restenosis via promoting proliferation and migration of vascular smooth muscle cells"],"prefix":"10.1111","volume":"24","author":[{"given":"Zhiwei","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Endocrinology Qilu Hospital  Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Endocrinology Yantai Affiliated Hospital of Binzhou Medical University  Yantai 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Shandong University  Jinan China"},{"name":"Key Laboratory of Endocrine and Metabolic Diseases Shandong Province medicine and health  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Qilu Hospital  Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Institute of Endocrine and Metabolic Diseases of Shandong University  Jinan China"},{"name":"Key Laboratory of Endocrine and Metabolic Diseases Shandong Province medicine and health  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Qilu Hospital  Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Institute of Endocrine and Metabolic Diseases of Shandong University  Jinan China"},{"name":"Key Laboratory of Endocrine and Metabolic Diseases Shandong 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