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Increasing evidence suggests that circular RNAs (circRNAs) serve as genomic regulatory molecules in various human cancers. Our initial in silico microarray\u2010based analysis identified that circRNA circ_001842 was highly expressed in RCC. Such up\u2010regulation of circ_001842 in RCC was experimentally validated in tissues and cell lines using RT\u2010qPCR. Thereafter, we attempted to identify the role of circ_001842 in the pathogenesis of RCC. Through a series of gain\u2010 and loss\u2010of function assays, cell biological functions were examined using colony formation assay, Transwell assay, annexin V\u2010FITC\/PI\u2010labelled flow cytometry and scratch test. A high expression of circ_001842 in tissues was observed as associated with poor prognosis of RCC patients. circ_001842 was found to elevate SLC39A14 expression by binding to miR\u2010502\u20105p, consequently resulting in augmented RCC cell proliferation, migration and invasion, as well as EMT in vitro and tumour growth in vivo. These observations imply the involvement of circ_001842 in RCC pathogenesis through a miR\u2010502\u20105p\u2010dependent SLC39A14 mechanism, suggesting circ_001842 is a potential target for RCC treatment.<\/jats:p>","DOI":"10.1111\/jcmm.15529","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T09:39:15Z","timestamp":1596101955000},"page":"9712-9725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Circular RNA circ_001842 plays an oncogenic role in renal cell carcinoma by disrupting microRNA\u2010502\u20105p\u2010mediated inhibition of SLC39A14"],"prefix":"10.1111","volume":"24","author":[{"given":"Jiawei","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Mianyang Central Hospital Mianyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery Mianyang Central Hospital Mianyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pathology Mianyang Central Hospital Mianyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanmeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Affiliated Hospital of Southwest Medical University Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Mianyang Central Hospital Mianyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-0432","authenticated-orcid":false,"given":"Jiafu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Mianyang Central Hospital Mianyang China"},{"name":"Department of Medical Laboratory Affiliated Hospital of Southwest Medical University Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.82"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyz013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.10.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29092"},{"key":"e_1_2_8_9_1","article-title":"iCircDA\u2010MF: identification of circRNA\u2010disease associations based on matrix factorization","author":"Wei H","year":"2019","journal-title":"Brief Bioinform"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00428"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1553354"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27744"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19154"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.11.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2016.01.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3105"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.167"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/celldisc.2017.25"},{"key":"e_1_2_8_19_1","first-page":"486","article-title":"Analysis the prognostic values of solute carrier (SLC) family 39 genes in gastric cancer","volume":"11","author":"Ding B","year":"2019","journal-title":"Am J Transl Res"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S103640"},{"key":"e_1_2_8_21_1","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. 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