{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:32:09Z","timestamp":1767166329188,"version":"build-2238731810"},"reference-count":33,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Noise\u2010induced hearing loss (NIHL) is one of the most frequent disabilities in industrialized countries. Evidence shows that hair cell loss in the auditory end organ is responsible for the majority of various ear pathological conditions. The functional roles of the receptor tyrosine kinase ROR1 have been underscored in various tumours. In this study, we evaluated the ability of ROR1 to influence cochlear hair cell loss of guinea pigs with NIHL. The NIHL model was developed in guinea pigs, with subsequent measurement of the auditory brainstem response (ABR). Gain\u2010of\u2010function experiments were employed to explore the role of ROR1 in NIHL. The interaction between ROR1 and Wnt5a and their functions in the cochlear hair cell loss were further analysed in response to alteration of ROR1 and Wnt5a. Guinea pigs with NIHL demonstrated elevated ABR threshold and down\u2010regulated ROR1, Wnt5a and NF\u2010\u03baB p65. The up\u2010regulation of ROR1 was shown to decrease the cochlear hair cell loss and the expression of pro\u2010apoptotic gene (Bax, p53) in guinea pig cochlea, but promoted the expression of anti\u2010apoptotic gene (Bcl\u20102) and the fluorescence intensity of cleaved\u2010caspase\u20103. ROR1 interacted with Wnt5a to activate the NF\u2010\u03baB signalling pathway through inducing phosphorylation and translocation of p65. Furthermore, Wnt5a overexpression decreased the cochlear hair cell loss. Collectively, this study suggested the protection of overexpression of ROR1 against cochlear hair cell loss in guinea pigs with NIHL\n                    <jats:italic>via<\/jats:italic>\n                    the Wnt5a\u2010dependent NF\u2010\u03baB signalling pathway.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15545","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T03:30:18Z","timestamp":1594092618000},"page":"9101-9113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Retracted:<\/i>\n                    Ectopic expression of ROR1 prevents cochlear hair cell loss in guinea pigs with noise\u2010induced hearing loss"],"prefix":"10.1111","volume":"24","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Children\u2019s Rehabilitation Linyi People\u2019s Hospital Linyi 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