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Hypothermia up\u2010regulates RNA\u2010binding motif protein 3 (RBM3), which is verified to protect synaptic plasticity. Here, we found that cognitive and LTP deficits, loss of spines, AD\u2010like tau pathologies are displayed one month after TBI in mice. In contrast, the deficits of LTP and cognitive, loss of spines and tau abnormal phosphorylation at several sites are obviously reversed in TBI mice combined with hypothermia pre\u2010treatment (HT). But, the neuroprotective role of HT disappears in TBI mouse models under condition of blocking RBM3 expression with RBM3 shRNA. In other hand, overexpressing RBM3 by AAV\u2010RBM3 plasmid can mimic HT\u2010like neuroprotection against TBI\u2010induced chronic brain injuries, such as improving LTP and cognitive, loss of spines and tau hyperphosphorylation in TBI mouse models. Taken together, hypothermia pre\u2010treatment reverses TBI\u2010induced chronic AD\u2010like pathology and behaviour deficits in RBM3 expression dependent manner, RBM3 may be a potential target for neurodegeneration diseases including Alzheimer disease.<\/jats:p>","DOI":"10.1111\/jcmm.15555","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T08:26:08Z","timestamp":1594369568000},"page":"9176-9188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The overexpression of RBM3 alleviates TBI\u2010induced behaviour impairment and AD\u2010like tauopathy in mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Bingjin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology Key Laboratory of Neurological Diseases of Education Ministry Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"School of Medicine and 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