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IHC and Western blot were carried out to analyse the expression of CSE, CHOP and active caspase3 in I\/R mice and hypoxia\/reoxygenation (H\/R) cells. TUNEL assay and flow cytometry were used to assess the apoptotic status of I\/R mice and H\/R cells. MTT was performed to analyse the proliferation of H\/R cells. H2S assay was used to evaluate the concentration of H2S in the myocardial tissues and peripheral blood of I\/R mice. I\/R\u2010induced mediated myocardial injury and apoptosis were partially reversed by methionine\u2010restricted diet (MRD) via the down\u2010regulation of CSE expression and up\u2010regulation of CHOP and active caspase3 expression. The decreased H2S concentration in myocardial tissues and peripheral blood of I\/R mice was increased by MRD. Accordingly, in a cellular model of I\/R injury established with H9C2 cells, cell proliferation was inhibited, cell apoptosis was increased, and the expressions of CSE, CHOP and active caspase3 were dysregulated, whereas NaHS treatment alleviated the effect of I\/R injury in H9C2 cells in a dose\u2010dependent manner. This study provided a deep insight into the mechanism underlying the role of MRD in I\/R\u2010induced myocardial injury.<\/jats:p>","DOI":"10.1111\/jcmm.15578","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T12:54:18Z","timestamp":1597323258000},"page":"9890-9897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dietary methionine restriction attenuates renal ischaemia\/reperfusion\u2010induced myocardial injury by activating the CSE\/H2S\/ERS pathway in diabetic mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Yuanyuan","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Gerontology Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People\u2019s Hospital Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Gerontology 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