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Expression of Muscle RING finger 1 (MuRF1), an E3 ubiquitin ligase, was increased to induce the loss of muscle mass in diabetic condition. However, hydrogen sulphide (H<jats:sub>2<\/jats:sub>S) plays a crucial role in the variety of physiological functions, including antihypertension, antiproliferation and antioxidant. In this study, db\/db mice and C2C12 myoblasts treated by high glucose and palmitate and oleate were chose as animal and cellular models. We explored how exogenous H<jats:sub>2<\/jats:sub>S attenuated the degradation of skeletal muscle via the modification of MuRF1 S\u2010sulfhydration in db\/db mice. Our results show cystathionine\u2010r\u2010lyase expression, and H<jats:sub>2<\/jats:sub>S level in skeletal muscle of db\/db mice was reduced. Simultaneously, exogenous H<jats:sub>2<\/jats:sub>S could alleviate ROS production and reverse expression of ER stress protein markers. Exogenous H<jats:sub>2<\/jats:sub>S could decrease the ubiquitination level of MYOM1 and MYH4 in db\/db mice. In addition, exogenous H<jats:sub>2<\/jats:sub>S reduced the interaction between MuRF1 with MYOM1 and MYH4 via MuRF1 S\u2010sulfhydration. Based on these results, we establish that H<jats:sub>2<\/jats:sub>S prevented the degradation of skeletal muscle via MuRF1 S\u2010sulfhydration at the site of Cys44 in db\/db mice.<\/jats:p>","DOI":"10.1111\/jcmm.15587","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T05:43:01Z","timestamp":1594100581000},"page":"9362-9377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hydrogen sulphide ameliorating skeletal muscle atrophy in db\/db mice via Muscle RING finger 1 S\u2010sulfhydration"],"prefix":"10.1111","volume":"24","author":[{"given":"Fangping","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoling","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Infectious The Fourth Hospital of Harbin Medical University 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