{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:25:13Z","timestamp":1789568713143,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272265"],"award-info":[{"award-number":["81272265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81472658"],"award-info":[{"award-number":["81472658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DNA methylation is an important biological regulatory mechanism that changes gene expression without altering the DNA sequence. Increasing studies have revealed that DNA methylation data play a vital role in the field of oncology. However, the methylation site signature in triple\u2010negative breast cancer (TNBC) remains unknown. In our research, we analysed 158 TNBC samples and 98 noncancerous samples from The Cancer Genome Atlas (TCGA) in three phases. In the discovery phase, 86 CpGs were identified by univariate Cox proportional hazards regression (CPHR) analyses to be significantly correlated with overall survival (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). In the training phase, these candidate CpGs were further narrowed down to a 15\u2010CpG\u2010based signature by conducting least absolute shrinkage and selector operator (LASSO) Cox regression in the training set. In the validation phase, the 15\u2010CpG\u2010based signature was verified using two different internal sets and one external validation set. Furthermore, a nomogram comprising the CpG\u2010based signature and TNM stage was generated to predict the 1\u2010, 3\u2010 and 5\u2010year overall survival in the primary set, and it showed excellent performance in the three validation sets (concordance indexes: 0.924, 0.974 and 0.637). This study showed that our nomogram has a precise predictive effect on the prognosis of TNBC and can potentially be implemented for clinical treatment and diagnosis.<\/jats:p>","DOI":"10.1111\/jcmm.15588","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:24:41Z","timestamp":1594373081000},"page":"9378-9387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Development and validation of a novel 15\u2010CpG\u2010based signature for predicting prognosis in triple\u2010negative breast cancer"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-8369","authenticated-orcid":false,"given":"Yang","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Endocrine and Breast Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing 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