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MiR\u201030b targeted and degraded sema3A mRNA. MiR\u201030b regulated the formation of sema3A\u2010NRP\u20101\u2010PlexinA1 complex via targeting sema3A. The neurite length was induced by the miR\u201030b agomir, and the application of sema3A protein could reverse the effect of agomir. GTP\u2010RhoA and ROCK expression were down\u2010regulated by miR\u201030b. Neurite outgrowth that inhibited by sema3A and the miR\u201030b antagomir was increased by Y\u201027632. Agomir promoted neurite growth in NogoA inhibitory conditions, which indicated miR\u201030b could both enhance neuronal intrinsic regenerative ability and promote neurite growth against inhibitory microenvironment via Sema3A\/NRP\u20101\/PlexinA1\/RhoA\/ROCK axis. The agomir could also regulate Sema3A\/NRP\u20101\/PlexinA1\/RhoA\/ROCK axis in vivo and restore spinal cord sensory conductive function. In conclusion, miR\u201030b could be a novel target for sensation recovery after SCI.<\/jats:p>","DOI":"10.1111\/jcmm.15591","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T17:54:06Z","timestamp":1601056446000},"page":"12285-12297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["miR\u201030b Promotes spinal cord sensory function recovery via the Sema3A\/NRP\u20101\/PlexinA1\/RhoA\/ROCK Pathway"],"prefix":"10.1111","volume":"24","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Chengde Medical University Chengde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-0583","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University Guangzhou 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