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Abnormal development in small intestine is casually implicated in impaired growth performance. However, the exact mechanism is still unknown. In this present study, PGR piglets (aged 42\u00a0days) were employed as a good model to analyse changes in nutrient absorption and energy metabolism in the intestinal mucosa. The results showed lower serum concentrations of free amino acids, and lipid metabolites in PGR piglets, which were in accordance with the down\u2010regulated mRNA expressions involved in fatty acid and amino acid transporters in the jejunal and ileal mucosa. The decreased activities of digestive enzymes and the marked swelling in mitochondria were also observed in the PGR piglets. In addition, it was found that lower ATP production, higher AMP\/ATP ratio, deteriorated mitochondrial complex III and ATP synthase, and decreased manganese superoxide dismutase activity in the intestinal mucosa of PGR piglets. Furthermore, altered gene expression involved in energy metabolism, accompanied by decreases in the protein abundance of SIRT1, PGC\u20101\u03b1 and PPAR\u03b3, as well as phosphorylations of AMPK\u03b1, mTOR, P70S6K and 4E\u2010BP1 were observed in intestinal mucosa of PGR piglets. In conclusion, decreased capability of nutrient absorption, mitochondrial dysfunction, and aberrant energy status in the jejunal and ileal mucosa may contribute to PGR piglets.<\/jats:p>","DOI":"10.1111\/jcmm.15621","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T09:35:30Z","timestamp":1594805730000},"page":"10100-10111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Postnatal growth retardation is associated with intestinal mucosa mitochondrial dysfunction and aberrant energy status in piglets"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-4931","authenticated-orcid":false,"given":"Ming","family":"Qi","sequence":"first","affiliation":[{"name":"Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro\u2010ecological Processes in Subtropical Region National Engineering Laboratory for Pollution Control 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