{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:22:02Z","timestamp":1790500922772,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570365"],"award-info":[{"award-number":["81570365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apela was recently identified as a new ligand of the apelin peptide jejunum (APJ) receptor. The purpose of this study was to investigate the role of apela in post\u2010myocardial infarction (post\u2010MI) recovery from cardiorenal damage. A murine MI model was established, and apela was then infused subcutaneously for two weeks. Echocardiographs were performed before and after infarction at the indicated times. Renal function was evaluated by serum and urine biochemistry. Immunohistochemistry of heart and kidney tissue was performed by in situ terminal deoxynucleotidyl transferase\u2010mediated dUPT nick end\u2010labelling reaction. Compared to the control group (MI\/vehicle), the average value of the left ventricular ejection fraction in apela\u2010treated mice increased by 32% and 39% at 2\u2010 and 4\u2010week post\u2010MI, respectively. The mean levels of serum blood urea nitrogen\uff0ccreatinine, N\u2010terminal pro\u2010brain natriuretic peptide and 24\u2010hour urine protein were significantly decreased at 4\u2010week post\u2010MI in apela\u2010treated mice relative to that of control animals. At the cellular level, we found that apela treatment significantly reduced myocardial fibrosis and cellular apoptosis in heart and kidney tissue. These data suggest that apela improves cardiac and renal function in mice with acute MI. The peptide may be potential therapeutic agent for heart failure.<\/jats:p>","DOI":"10.1111\/jcmm.15651","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T12:58:53Z","timestamp":1595249933000},"page":"10382-10390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Apela improves cardiac and renal function in mice with acute myocardial infarction"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5612-4975","authenticated-orcid":false,"given":"Yang","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Nanjing Brain Hospital Nanjing Medical University Nanjing China"},{"name":"Department of Cardiovascular Medicine Nanjing Chest Hospital Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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