{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T11:03:12Z","timestamp":1771412592713,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302282"],"award-info":[{"award-number":["81302282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873195"],"award-info":[{"award-number":["81873195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["20170540273"],"award-info":[{"award-number":["20170540273"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dihydrotanshinone I (DHTS), extracted from Salvia miltiorrhiza, was found to be the most effective compound of tanshen extracts against cancer cells in our previous studies. However, the therapeutic benefits and underlying mechanisms of DHTS on ovarian cancer remain uncertain. In this study, we demonstrated the cytocidal effects of DHTS on chemosensitive ovarian cancer cells with or without platinum\u2010based chemotherapy. DHTS was able to inhibit proliferation and migration of ovarian cancer cells in vitro and in vivo through modulation of the PI3K\/AKT signalling pathways. Combinatorial treatment of DHTS and cisplatin exhibited enhanced DNA damage in ovarian cancer cells. Overall, these findings suggest that DHTS induces ovarian cancer cells death via induction of DNA damage and inhibits ovarian cancer cell proliferation and migration.<\/jats:p>","DOI":"10.1111\/jcmm.15660","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T03:30:11Z","timestamp":1598671811000},"page":"11177-11187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaoqing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"},{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-413X","authenticated-orcid":false,"given":"Xiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-1661","authenticated-orcid":false,"given":"Guoqiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Likun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Owusu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Basic Medical School Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liye","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-9156","authenticated-orcid":false,"given":"Weiling","family":"Li","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/CA.2007.0010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.01.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1123"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3084"},{"key":"e_1_2_10_9_1","first-page":"721","article-title":"New advances in ovarian cancer","volume":"24","author":"Liu J","year":"2010","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.51.1.15"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.07.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.12.041"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131013621"},{"key":"e_1_2_10_15_1","first-page":"1377","article-title":"Cytotoxic and apoptotic effects of root extract and tanshinones isolated from Perovskiaabrotanoides Kar","volume":"20","author":"Zaker A","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.12.051"},{"key":"e_1_2_10_17_1","first-page":"2694","article-title":"The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3\/Smad7 cascade","volume":"9","author":"Zhong C","year":"2017","journal-title":"Am J Transl Res"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5408"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401556"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01277-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.08.009"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.17305\/bjbms.2017.1800","article-title":"Salvia miltiorrhiza extract dihydrotanshinone induces apoptosis and inhibits proliferation of glioma cells","volume":"17","author":"Cao Y","year":"2017","journal-title":"Bosn J Basic Med Sci"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666151019092919"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160819387"},{"key":"e_1_2_10_25_1","first-page":"3225","article-title":"15,16\u2010Dihydrotanshinone I\u2010induced apoptosis in human colorectal cancer cells: involvement of ATF3","volume":"33","author":"Suk FM","year":"2013","journal-title":"Anticancer Res"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-1723(00)88838-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8419"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.023"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.12.024"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0170"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802655105"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-118907"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.02.003"},{"key":"e_1_2_10_35_1","first-page":"58","article-title":"The characteristics of atherosclerosis based on autopsy data of Yakutsk","volume":"8","author":"Alekseev VP","year":"1968","journal-title":"Kardiologiia"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds315"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.195"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1489"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a130272"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30469-2"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32440-6"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7549"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40661-016-0033-6"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S52379"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.09.050"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2741\/e786"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.326"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8769"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1236188"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-12-0401"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00051"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.56"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0020"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15660","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T10:08:17Z","timestamp":1771409297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,29]]},"references-count":52,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jcmm.15660"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15660","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,29]]},"assertion":[{"value":"2020-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}