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Although the pathogenesis of OA remains poorly understood, synovial inflammation is known to play an important role in OA development. However, studies on OA pathophysiology have focused more on cartilage degeneration and osteophytes, rather than on the inflamed and thickened synovium. Fibroblast\u2010like synoviocytes (FLS) produce a series of pro\u2010inflammatory regulators, such as inflammatory cytokines, nitric oxide (NO) and prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ). These regulators are positively associated with the clinical symptoms of OA, such as inflammatory pain, joint swelling and disease development. A better understanding of the inflammatory immune response in OA\u2010FLS could provide a novel approach to comprehensive treatment strategies for OA. Here, we have summarized recently published literatures referring to epigenetic modifications, activated signalling pathways and inflammation\u2010associated factors that are involved in OA\u2010FLS\u2010mediated inflammation. In addition, the current related clinical trials and future perspectives were also summarized.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15669","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T21:49:05Z","timestamp":1595195345000},"page":"9518-9532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["The emerging role of fibroblast\u2010like synoviocytes\u2010mediated synovitis in osteoarthritis: An update"],"prefix":"10.1111","volume":"24","author":[{"given":"Dafei","family":"Han","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacology Key Laboratory of Anti\u2010Inflammatory and Immune Medicine Ministry of Education Anhui Collaborative Innovation Center of Anti\u2010Inflammatory and Immune Medicine Anhui Medical University Hefei 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