{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:00:25Z","timestamp":1769637625311,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The case\u2010control study was designed to investigate the genetic effects of interferon\u2010gamma (<jats:italic>IFN\u2010\u03b3<\/jats:italic>) rs2069727 and rs1861494 polymorphisms on ankylosing spondylitis (AS) susceptibility in a Chinese Han population. Blood samples were collected from 108 AS patients and 110 healthy controls. <jats:italic>IFN\u2010\u03b3<\/jats:italic> polymorphisms were genotyped by polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP). Hardy\u2010Weinberg equilibrium (HWE) test was performed in control group. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using chi\u2010square test to evaluate the association between AS susceptibility and <jats:italic>IFN\u2010\u03b3<\/jats:italic> polymorphisms, and the results were adjusted by logistic regressive analysis. The frequency of rs2069727 CC genotype was much higher in cases than that in controls, suggested its significant association with increased AS risk (adjusted OR\u00a0=\u00a05.899, 95% CI\u00a0=\u00a01.563\u201022.261; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009). In addition, C allele also showed close association with increased risk of AS (adjusted OR\u00a0=\u00a02.052, 95% CI\u00a0=\u00a01.286\u20101.704, <jats:italic>P\u200a\u00a0<\/jats:italic>=\u00a00\u200a.003). While the genotype and allele frequencies of <jats:italic>IFN\u2010\u03b3<\/jats:italic> rs1861494 polymorphism were not significantly different between patients and controls (<jats:italic>P\u200a\u00a0<\/jats:italic>&gt;\u00a00.05 for all), <jats:italic>IFN\u2010\u03b3<\/jats:italic> rs2069727 polymorphism is significantly associated with increased AS risk in a Chinese Han Population.<\/jats:p>","DOI":"10.1111\/jcmm.15680","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T11:50:16Z","timestamp":1596109816000},"page":"10615-10620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of <i>IFN\u2010\u03b3<\/i> polymorphisms with ankylosing spondylitis risk"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2750-2353","authenticated-orcid":false,"given":"Yanhui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of 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