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However, its effects on yolk sac morphology and function are largely unexplored. We hypothesized that MiP modifies yolk sac morphology and efflux transport potential by modulating ABC efflux transporters. C57BL\/6 mice injected with\n                    <jats:italic>Plasmodium berghei ANKA<\/jats:italic>\n                    (5\u00a0\u00d7\u00a010\n                    <jats:sup>5<\/jats:sup>\n                    infected erythrocytes) at gestational day (GD) 13.5 were subjected to yolk sac membrane harvesting at GD 18.5 for histology, qPCR and immunohistochemistry. MiP did not alter the volumetric proportion of the yolk sac's histological components. However, it increased levels of\n                    <jats:italic>Abcb1a<\/jats:italic>\n                    mRNA (encoding P\u2010glycoprotein) and macrophage migration inhibitory factor (\n                    <jats:italic>Mif<\/jats:italic>\n                    chemokine), while decreasing\n                    <jats:italic>Abcg1<\/jats:italic>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05); without altering\n                    <jats:italic>Abca1, Abcb1b, Abcg2, Snat1, Snat2<\/jats:italic>\n                    , interleukin\n                    <jats:italic>(Il)\u20101\u03b2<\/jats:italic>\n                    and C\u2010C Motif chemokine ligand 2 (\n                    <jats:italic>Ccl2<\/jats:italic>\n                    ). Transcripts of\n                    <jats:italic>Il\u20106<\/jats:italic>\n                    , chemokine (C\u2010X\u2010C motif) ligand 1 (\n                    <jats:italic>Cxcl1<\/jats:italic>\n                    ),\n                    <jats:italic>Glut1<\/jats:italic>\n                    and\n                    <jats:italic>Snat4<\/jats:italic>\n                    were not detectible. ABCA1, ABCG1, breast cancer resistance protein (BCRP) and P\u2010gp were primarily immunolocalized to the cell membranes and cytoplasm of endodermic epithelium but also in the mesothelium and in the endothelium of mesodermic blood vessels. Intensity of P\u2010gp labelling was stronger in both endodermic epithelium and mesothelium, whereas ABCA1 labelling increased in the endothelium of the mesodermic blood vessels. The presence of ABC transporters in the yolk sac wall suggests that this fetal membrane acts as an important protective gestational barrier. Changes in ABCA1 and P\u2010gp in MiP may alter the biodistribution of toxic substances, xenobiotics, nutrients and immunological factors within the fetal compartment and participate in the pathogenesis of malaria\u2010induced IUGR and PTL.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15682","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T22:06:16Z","timestamp":1597183576000},"page":"10636-10647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Malaria in pregnancy regulates P\u2010glycoprotein (P\u2010gp\/\n                    <i>Abcb1a<\/i>\n                    ) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac"],"prefix":"10.1111","volume":"24","author":[{"given":"Lilian M.","family":"Martinelli","sequence":"first","affiliation":[{"name":"Department of Morphology Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus N.","family":"Fontes","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Endocrinology Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila W.","family":"Reginatto","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Endocrinology Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherley B. 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S.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Endocrinology Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanailly R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Endocrinology Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao L.","family":"Silva\u2010Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Biochemistry of Parasitic Diseases Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana A. S.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Biochemistry of Parasitic Diseases Institute of Biophysics Carlos Chagas Filho Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria R.","family":"Vago","sequence":"additional","affiliation":[{"name":"Department of Morphology Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda R. C. 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