{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:19:30Z","timestamp":1788121170110,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81403332"],"award-info":[{"award-number":["81403332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603559"],"award-info":[{"award-number":["81603559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>QiShenYiQi pill (QSYQ), a traditional Chinese medicine, is well known for improving the myocardial remodelling, but the dose\u2010effect relationship of its intervention in the reparative myocardial fibrosis is still unclear. We investigated the effect of QSYQ on the reparative myocardial fibrosis in cardiac myosin\u2010induced rats and explored its mechanism of action by regulating autophagy. The results indicated that QSYQ increased LVEF and LVFS, and decreased the LVEDD, LVESD, HMI, LVMI, myocardial inflammation histology score, and collagen volume fraction in a dose\u2010dependent manner. In addition, QSYQ declined the number of autophagosomes, down\u2010regulated the expression of myocardial Beclin\u20101 and LC3B, up\u2010regulated the expression of myocardial p62 and increased the ratios of myocardial p\u2010PI3K\/PI3K, p\u2010Akt\/Akt and p\u2010mTOR\/mTOR. We provided evidence for that QSYQ could inhibit excessive myocardial autophagy by regulating the PI3K\/Akt\u2010mTOR pathway and can be a potential therapeutic approach in treating the cardiovascular diseases such as myocarditis and dilated cardiomyopathy.<\/jats:p>","DOI":"10.1111\/jcmm.15695","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:11:49Z","timestamp":1599091909000},"page":"11283-11293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["QiShenYiQi pill improves the reparative myocardial fibrosis by regulating autophagy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4073-9083","authenticated-orcid":false,"given":"Shichao","family":"Lv","sequence":"first","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China"},{"name":"Tianjin Key Laboratory of Traditional Research of 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