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Angiopoietin\u2010like protein 4 (ANGPTL4) acts as a multifunctional secretory protein and is involved in the regulation of lipid metabolism and angiogenesis in various tissues including the endometrium. Herein, we found decreased ANGPTL4 expression in endometrial tissue and serum during peri\u2010implantation period in 18 RIF\u2010affected women with elevated uterine arterial impedance (UAI) compared with the pregnancy controls. ANGPTL4 and peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) expression were up\u2010regulated upon decidualization on human endometrial stromal cells (HESCs). Rosiglitazone promoted the expression of ANGPTL4 in HESCs and human umbilical vein endothelial cells (HUVECs) via PPAR\u03b3. ANGPTL4 promoted the proliferation, migration and angiogenesis of HUVECs in vitro. Our results suggest that decreased abundance of ANGPTL4 in endometrial tissues impairs the endometrial receptivity via restraining endometrial angiogenesis during decidualization; while rosiglitazone\u2010induced ANGPTL4 up\u2010regulation in hESCs and HUVECs through PPAR\u03b3. Therefore, ANGPTL4 could be a potential therapeutic approach for some RIF\u2010affected women with elevated UAI.<\/jats:p>","DOI":"10.1111\/jcmm.15696","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T18:11:03Z","timestamp":1596478263000},"page":"10730-10743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Decreased ANGPTL4 impairs endometrial angiogenesis during peri\u2010implantation period in patients with recurrent implantation failure"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-2935","authenticated-orcid":false,"given":"Mingyang","family":"Li","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 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