{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:21:03Z","timestamp":1783455663837,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Science and Technology Project grant of Guangdong Province","award":["2014B020210001"],"award-info":[{"award-number":["2014B020210001"]}]},{"name":"Science and Technology innovation Project of Foshan","award":["2017IT100162"],"award-info":[{"award-number":["2017IT100162"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, we have investigated potential cardioprotective properties of Isosteviol analogue we recently synthesized and named JC105. Treatment of heart embryonic H9c2 cells with JC105 (10\u00a0\u03bcM) significantly increased survival of cells exposed to hypoxia\u2010reoxygenation. JC105 (10\u00a0\u03bcM) activated ERK1\/2, DRP1 and increased levels of cardioprotective SUR2A in hypoxia\u2010reoxygenation, but did not have any effects on ERK1\/2, DRP1 and\/or SUR2A in normoxia. U0126 (10\u00a0\u03bcM) inhibited JC105\u2010mediated phosphorylation of ERK1\/2 and DRP1 without affecting AKT or AMPK, which were also not regulated by JC105. Seahorse bioenergetic analysis demonstrated that JC105 (10\u00a0\u03bcM) did not affect mitochondria at rest, but it counteracted all mitochondrial effects of hypoxia\u2010reoxygenation. Cytoprotection afforded by JC105 was inhibited by U0126 (10\u00a0\u03bcM). Taken all together, these demonstrate that (a) JC105 protects H9c2 cells against hypoxia\u2010reoxygenation and that (b) this effect is mediated via ERK1\/2. The unique property of JC105 is that selectively activates ERK1\/2 in cells exposed to stress, but not in cells under non\u2010stress conditions.<\/jats:p>","DOI":"10.1111\/jcmm.15721","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T04:42:09Z","timestamp":1597466529000},"page":"10924-10934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cardioprotection by isosteviol derivate JC105: A unique drug property to activate ERK1\/2 only when cells are exposed to hypoxia\u2010reoxygenation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-5433","authenticated-orcid":false,"given":"Khaja Shameem","family":"Mohammed Abdul","sequence":"first","affiliation":[{"name":"Institute of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayachandra","family":"Rayadurgam","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou PR China"},{"name":"Research Center for Drug Discovery School of Pharmaceutical Sciences Sun Yat\u2010Sen University Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Faiz","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-9318","authenticated-orcid":false,"given":"Aleksandar","family":"Jovanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Sciences University of Nicosia Medical School Nicosia Cyprus"},{"name":"Centre for Neuroscience and Integrative Brain Research (CENIBRE) University of Nicosia Medical School Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou PR China"},{"name":"Jeffrey Cheah School of Medicine and Health Sciences Monash University Malaysia Selangor Darul Ehsan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.06.029"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.052"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.05.033"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2007.06.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.07.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14122"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092164"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303051200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.01.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.069"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5483com"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.01.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22969"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0501-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7120195"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.10.029"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00042.2018"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400755"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.05.013"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.15721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T16:59:32Z","timestamp":1692550772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":19,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/jcmm.15721"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15721","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"assertion":[{"value":"2020-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}