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Recently, sodium hydrosulfide (NaHS) has been found to have neuroprotective properties. Our study addressed whether NaHS could rescue DA\u2010challenged inflammation and apoptosis in neurons to ameliorate memory impairment in MHE rats and in the neuron and astrocyte coculture system. We found that NaHS suppressed DA\u2010induced p65 acetylation, resulting in reduced TNF\u2010\u03b1 production in astrocytes both in vitro and in vivo. Furthermore, decreased apoptosis was observed in neurons exposed to conditioned medium from DA\u00a0+\u00a0NaHS\u2010challenged astrocytes, which was similar to the results obtained in the neurons exposed to TNF\u2010\u03b1\u00a0+\u00a0NaHS, suggesting a therapeutic effect of NaHS on the suppression of neuronal apoptosis via the reduction of TNF\u2010\u03b1 level. DA triggered the inactivation of p70 S6 ribosomal kinase (S6K1) and dephosphorylation of Bad, resulting in the disaggregation of Bclxl and Bak and the release of cytochrome c (Cyt. c), and this process could be reversed by NaHS administration. Our work demonstrated that NaHS attenuated DA\u2010induced astrocytic TNF\u2010\u03b1 release and ameliorated inflammation\u2010induced neuronal apoptosis in MHE. Further research into this approach may uncover future potential therapeutic strategies for MHE.<\/jats:p>","DOI":"10.1111\/jcmm.15728","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T06:56:56Z","timestamp":1603954616000},"page":"13634-13647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hydrogen sulphide ameliorates dopamine\u2010induced astrocytic inflammation and neurodegeneration in minimal hepatic encephalopathy"],"prefix":"10.1111","volume":"24","author":[{"given":"Weishan","family":"Zhuge","sequence":"first","affiliation":[{"name":"Gastrointestinal Surgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qichuan","family":"Zhuge","sequence":"additional","affiliation":[{"name":"Neurosurgery Department The First Affiliated Hospital of Wenzhou Medical University Wenzhou 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