{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:10:19Z","timestamp":1789092619670,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNAs (miRNAs) have already been proposed to be implicated in the development of ischaemic stroke. We aim to investigate the role of miR\u2010130a in the neurological deficit and angiogenesis in rats with ischaemic stroke by regulating X\u2010linked inhibitor of apoptosis protein (XIAP). Middle cerebral artery occlusion (MCAO) models were established by suture\u2010occluded method, and MCAO rats were then treated with miR\u2010130a mimics\/inhibitors or\/and altered XIAP for detection of changes of rats\u2019 neurological function, nerve damage and angiogenesis in MCAO rats. The oxygen\u2010glucose deprivation (OGD) cellular models were established and respectively treated to determine the roles of miR\u2010130a and XIAP in neuronal viability and apoptosis. The expression levels of miR\u2010130a and XIAP in brain tissues of MCAO rats and OGD\u2010treated neurons were detected. The binding site between miR\u2010130a and XIAP was verified by luciferase activity assay. MiR\u2010130a was overexpressed while XIAP was down\u2010regulated in MCAO rats and OGD\u2010treated neurons. In animal models, suppressed miR\u2010130a improved neurological function, alleviated nerve damage and increased new vessels in brain tissues of rats with MCAO. In cellular models, miR\u2010130a inhibition promoted neuronal viability and suppressed apoptosis. Inhibited XIAP reversed the effect of inhibited miR\u2010130a in both MCAO rats and OGD\u2010treated neurons. XIAP was identified as a target of miR\u2010130a. Our study reveals that miR\u2010130a regulates neurological deficit and angiogenesis in rats with MCAO by targeting XIAP.<\/jats:p>","DOI":"10.1111\/jcmm.15732","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T19:34:46Z","timestamp":1597347286000},"page":"10987-11000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["MicroRNA\u2010130a regulates neurological deficit and angiogenesis in rats with ischaemic stroke by targeting XIAP"],"prefix":"10.1111","volume":"24","author":[{"given":"Wenjing","family":"Deng","sequence":"first","affiliation":[{"name":"The Neurology Intensive Care Unit The First Affiliated of Zhengzhou University. Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghe","family":"Fan","sequence":"additional","affiliation":[{"name":"The Neurology Intensive Care Unit The First Affiliated of Zhengzhou University. 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