{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:15:13Z","timestamp":1791000913201,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accumulating evidence suggests that circular RNAs have the abilities to regulate gene expression during the progression of sepsis\u2010associated acute kidney injury. Circular RNA VMA21 (circVMA21), a recent identified circular RNA, could reduce apoptosis to alleviate intervertebral disc degeneration in rats and protect WI\u201038 cells from lipopolysaccharide\u2010induced injury. However, the role of circVMA21 in sepsis\u2010associated acute kidney injury (sepsis\u2010associated AKI) is unknown. In this study, we first demonstrated that circVMA21 alleviated sepsis\u2010associated AKI by reducing apoptosis and inflammation in rats and HK\u20102 cells. Additionally, to explore the molecule mechanism underlying the amelioration, after the bioinformatics analysis, we confirmed that miR\u20109\u20103p directly bound to circVMA21 by luciferase and RNA immunoprecipitation assay, and the effector protein of miR\u20109\u20103p was SMG1. Furthermore, the oxidative stress caused by sepsis\u2010associated AKI was down\u2010regulated by circVMA21. In conclusion, circVMA21 plays an important role in the regulating sepsis\u2010associated AKI via adjusting miR\u20109\u201039\/SMG1\/inflammation axis and oxidative stress.<\/jats:p>","DOI":"10.1111\/jcmm.15741","type":"journal-article","created":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T06:48:33Z","timestamp":1598078913000},"page":"11397-11408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Circular RNA VMA21 ameliorates sepsis\u2010associated acute kidney injury by regulating miR\u20109\u20103p\/SMG1\/inflammation axis and oxidative stress"],"prefix":"10.1111","volume":"24","author":[{"given":"Yan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Emergency The Affiliated Huai\u2019an Hospital of Xuzhou Medical University and The Second People\u2019s Hospital of Huai\u2019an Huai\u2019an 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