{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:30:10Z","timestamp":1788388210195,"version":"build-2803163510"},"reference-count":100,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis and psoriatic arthritis are multifactorial chronic disorders whose etiopathogenesis essentially derives from the alteration of several signalling pathways and the co\u2010occurrence of genetic, epigenetic and non\u2010genetic susceptibility factors that altogether affect the functional and structural property of the skin. Although shared and differential susceptibility genes and molecular pathways are known to contribute to the onset of pathological phenotypes, further research is needed to dissect the molecular causes of psoriatic disease and its progression towards Psoriatic Arthritis. This review will therefore be addressed to explore differences and similarities in the etiopathogenesis and progression of both disorders, with a particular focus on genes involved in the maintenance of the skin structure and integrity (keratins and collagens), modulation of patterns of recognition (through Toll\u2010like receptors and dectin\u20101) and immuno\u2010inflammatory response (by NLRP3\u2010dependent inflammasome) to microbial pathogens. In addition, special emphasis will be given to the contribution of epigenetic elements (methylation pattern, non\u2010coding RNAs, chromatin modifiers and 3D genome organization) to the etiopathogenesis and progression of psoriasis and psoriatic arthritis. The evidence discussed in this review highlights how the knowledge of patients' clinical and (epi)genomic make\u2010up could be helpful for improving the available therapeutic strategies for psoriasis and psoriatic arthritis treatment.<\/jats:p>","DOI":"10.1111\/jcmm.15742","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T16:03:37Z","timestamp":1604160217000},"page":"13554-13563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Overview of the molecular determinants contributing to the expression of Psoriasis and Psoriatic Arthritis phenotypes"],"prefix":"10.1111","volume":"24","author":[{"given":"Valerio","family":"Caputo","sequence":"first","affiliation":[{"name":"Medical Genetics Laboratory Department of Biomedicine and Prevention Tor Vergata University Rome Italy"},{"name":"Genomic Medicine Laboratory UILDM IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Strafella","sequence":"additional","affiliation":[{"name":"Medical Genetics Laboratory Department of Biomedicine and Prevention Tor Vergata University Rome Italy"},{"name":"Genomic Medicine Laboratory UILDM IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Termine","sequence":"additional","affiliation":[{"name":"Genomic Medicine Laboratory UILDM IRCCS Santa Lucia Foundation Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata","family":"Dattola","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Department of Systems Medicine Tor Vergata University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mazzilli","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Department of Systems Medicine Tor Vergata University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Lanna","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Department of Systems Medicine Tor Vergata University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terenzio","family":"Cosio","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Department of Systems Medicine Tor Vergata University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Campione","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Department of Systems Medicine Tor Vergata University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Novelli","sequence":"additional","affiliation":[{"name":"Medical Genetics Laboratory Department of Biomedicine and Prevention Tor Vergata University Rome Italy"},{"name":"Neuromed Institute IRCCS Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Giardina","sequence":"additional","affiliation":[{"name":"Genomic Medicine Laboratory UILDM IRCCS Santa Lucia Foundation Rome Italy"},{"name":"Department of Biomedicine and Prevention UILDM Lazio Onlus Foundation Tor Vergata University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-0758","authenticated-orcid":false,"given":"Raffaella","family":"Cascella","sequence":"additional","affiliation":[{"name":"Medical Genetics Laboratory Department of Biomedicine and Prevention Tor Vergata University Rome Italy"},{"name":"Department of Biomedical Sciences Catholic University Our Lady of Good Counsel Tirana Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.446"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.88"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.398"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.06.022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12178"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.2004.00118.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.049"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1751-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.01.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22206.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05112.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13336"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1653099"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2014.68.236-238"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-1-65"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.16.20"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30340"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.07.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.023"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151093"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2016.1147954"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15659"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket296"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214158"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20727"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.12.019"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217710637"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.09.021"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14139"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.116574"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.033"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.222"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84870"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-2105-4"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0394-3"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051407"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00363"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.07.002"},{"issue":"107","key":"e_1_2_10_41_1","first-page":"116","article-title":"Hypermobility, the Ehlers\u2010Danlos syndromes and chronic pain","volume":"35","author":"Syx D","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2013.822865"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.284"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050242"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-128"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00923.x"},{"issue":"1187","key":"e_1_2_10_47_1","article-title":"A comprehensive analysis of the COL29A1 gene does not support a role in eczema","volume":"127","author":"Naumann A","year":"2011","journal-title":"J All Clin Immunol"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3457898"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082740"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.05.023"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23241"},{"key":"e_1_2_10_52_1","first-page":"446","article-title":"Assessing individual risk for AMD with genetic counseling, family history, and genetic testing","volume":"32","author":"Cascella R","year":"2018","journal-title":"Eye Lond. Engl"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1040-z"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0175-0"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2017.08.004"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16081"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000162107"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.28"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0121-3"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12572"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.07.013"},{"issue":"3","key":"e_1_2_10_62_1","first-page":"122","article-title":"The role of candida albicans in the pathogenesis of psoriasis vulgaris: a systematic literature review","volume":"3","author":"Sepahi S","year":"2016","journal-title":"Rev Cli. Med"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3893"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.196"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.395"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712590802494212"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms5020032"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2581-7"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.04.014"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1620-4"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2017.65628"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00832.x"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix153"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.10.011"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12049"},{"key":"e_1_2_10_76_1","doi-asserted-by":"crossref","unstructured":"ItoT MeyerKC ItoN et al.Immune Privilege and the Skin. In: Nickoloff BJ Nestle FO editors. Curr. Dir. Autoimmun. vol. 10 Basel: KARGER;2008 pp. 27\u201352.","DOI":"10.1159\/000131412"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.010"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.1.94"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144097"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.131912"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2016.09.003"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10646.x"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1473550"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.348"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.01.001"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0297-z"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.112"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006966"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201101148"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.026"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.110"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.040"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.36"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.009"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-019-0297-9"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002030"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.012"},{"key":"e_1_2_10_98_1","first-page":"113","article-title":"Characterisation of peripheral blood mononuclear cell microRNA in early onset psoriatic arthritis","volume":"35","author":"Ciancio G","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12469"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00701"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ht9010003"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15742","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:01:17Z","timestamp":1705060877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,31]]},"references-count":100,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/jcmm.15742"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15742","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,31]]},"assertion":[{"value":"2020-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}