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We found that the expression of circ_0060745 was significantly increased in the myocardium of AMI mice and was mainly expressed in myocardial fibroblasts. The knockdown of circ_0060745 decreased myocardial infarct size and improved systolic cardiac functions after AMI. The knockdown of circ_0060745 in cardiac fibroblasts inhibited the migration of peritoneal macrophage, the apoptosis of cardiomyocytes and the expressions of IL\u20106, IL\u201012, IL\u20101\u03b2, TNF\u2010\u03b1 and NF\u2010\u03baB under hypoxia. Overexpression of circ_0060745 caused an increase in infarct size and worsened cardiac functions after AMI. In summary, our findings showed that knockdown of circ_0060745 mitigates AMI by suppressing cardiomyocyte apoptosis and inflammation. These protective effects could be attributed to inhibition of NF\u2010\u03baB activation.<\/jats:p>","DOI":"10.1111\/jcmm.15748","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T21:53:50Z","timestamp":1601070830000},"page":"12401-12410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF\u2010\u03baB activation"],"prefix":"10.1111","volume":"24","author":[{"given":"Changlin","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases The Affiliated Hospital of Jiaxing University Zhejiang China"},{"name":"Jiaxing Institute of Atherosclerotic Disease Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases The Affiliated Hospital of 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