{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:28:23Z","timestamp":1790368103462,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fatty acid synthase (FASN) has been shown to be selectively up\u2010regulated in cancer cells to drive the development of cancer. However, the role and associated mechanism of FASN in regulating the malignant progression of salivary adenoid cystic carcinoma (SACC) still remains unclear. In this study, we demonstrated that FASN inhibition attenuated invasion, metastasis and EMT of SACC cells as well as the expression ofPRRX1, ZEB1, Twist, Slug and Snail, among which the level of PRRX1 changed the most obviously. Overexpression of PRRX1 restored migration and invasion in FASN knockdown cells, indicating that PRRX1 is an important downstream target of FASN signalling. Levels of cyclin D1 and c\u2010Myc, targets of Wnt\/\u03b2\u2010catenin pathway, were significantly decreased by FASN silencing and restored by PRRX1 overexpression. In addition, FASN expression was positively associated with metastasis and poor prognosis of SACC patients as well as with the expression of PRRX1, cyclin D1 and c\u2010Myc in SACC tissues. Our findings revealed that FASN in SACC progression may induce EMT in a PRRX1\/Wnt\/\u03b2\u2010catenin dependent manner.<\/jats:p>","DOI":"10.1111\/jcmm.15760","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T06:10:38Z","timestamp":1597990238000},"page":"11465-11476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["RETRACTED: Fatty acid synthase contributes to epithelial\u2010mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1\/Wnt\/\u03b2\u2010catenin pathway"],"prefix":"10.1111","volume":"24","author":[{"given":"Wei\u2010long","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Pathology State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology (Sichuan University)  Chengdu Sichuan 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Diseases West China Hospital of Stomatology (Sichuan University)  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology (Sichuan University)  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology (Sichuan University)  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology (Sichuan University)  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-8748","authenticated-orcid":false,"given":"Xin\u2010hua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology (Sichuan University)  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-3571","authenticated-orcid":false,"given":"Ya\u2010ling","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases West China Hospital of Stomatology (Sichuan University)  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