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Only 5%\u201010% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the contribution of other genes. Using a microarray gene expression profiling study of BC, we have recently identified\n                    <jats:italic>BRIP1<\/jats:italic>\n                    (fivefold up\u2010regulation) as a potential gene associated with BC progression in the Omani population. Although\n                    <jats:italic>BRIP1<\/jats:italic>\n                    regulates DNA repair and cell proliferation, the precise role of\n                    <jats:italic>BRIP1<\/jats:italic>\n                    in BC cell invasion\/metastasis has not been explored yet; this prompted us to test the hypothesis that\n                    <jats:italic>BRIP1<\/jats:italic>\n                    promotes BC cell proliferation and invasion. Using a combination of cellular and molecular approaches, our results revealed differential overexpression of\n                    <jats:italic>BRIP1<\/jats:italic>\n                    in different BC cell lines. Functional assays validated further the physiological relevance of\n                    <jats:italic>BRIP1<\/jats:italic>\n                    in tumour malignancy, and siRNA\u2010mediated\n                    <jats:italic>BRIP1<\/jats:italic>\n                    knockdown significantly reduced BC cell motility by targeting key motility\u2010associated genes. Moreover, down\u2010regulation of\n                    <jats:italic>BRIP1<\/jats:italic>\n                    expression significantly attenuated cell proliferation via cell cycle arrest. Our study is the first to show the novel function of\n                    <jats:italic>BRIP1<\/jats:italic>\n                    in promoting BC cell invasion by regulating expression of various downstream target genes. Furthermore, these findings provide us with a unique opportunity to identify\n                    <jats:italic>BRIP1<\/jats:italic>\n                    \u2010induced pro\u2010invasive genes that could serve as biomarkers and\/or targets to guide the design of appropriate BC targeted therapies.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15761","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T05:49:20Z","timestamp":1599284960000},"page":"11477-11488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Novel role of BRCA1 interacting C\u2010terminal helicase 1 (\n                    <i>BRIP1)<\/i>\n                    in breast tumour cell invasion"],"prefix":"10.1111","volume":"24","author":[{"given":"Balsam","family":"Rizeq","sequence":"first","affiliation":[{"name":"Department of Biological and Environmental Sciences College of Arts &amp; Sciences Qatar University Doha 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