{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T11:03:49Z","timestamp":1771412629804,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The IKK\u2010related kinases, IKK\u03b5 and TBK1, have essential roles in innate immunity in part through modifying MYD88 signalling from the Toll\u2010like receptors to regulate NF\u2010\u03baB signalling. We investigated the expression and function of IKK\u03b5 and TBK1, in diffuse large B\u2010cell lymphoma (DLBCL). DLBCL cell lines and patient\u2010derived xenografts were used to determine their sensitivity to IKK\u03b5 and TBK1 inhibitors. To understand the function of IKK\u03b5 and TBK1 secreted factors were determined following administration of inhibitors. Gene expression microarrays were used to determine the transcriptional effects of inhibitors. Higher\n                    <jats:italic>TBK1<\/jats:italic>\n                    mRNA levels associated with poorer clinical outcome but IKK\u03b5 and TBK1 were expressed in both germinal centre and non\u2010germinal centre types of DLBCL. Survival of cell lines Ly10, Ly03 and Pfeiffer, and of some primary human lymphoma cells, was suppressed by a small molecule IKK\u03b5\/TBK1 inhibitor, DMX3433. DMX3433 reduced IL\u201010 production from Ly10 and repressed NF\u2010\u03baB mediated transcription. Inhibition of IKK\u03b5 and TBK1 warrants further investigation as a potential therapeutic route to suppress NF\u2010\u03baB signalling in lymphoma.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15774","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T23:06:18Z","timestamp":1598655978000},"page":"11573-11582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["IKK\u03b5 and TBK1 in diffuse large B\u2010cell lymphoma: A possible mechanism of action of an IKK\u03b5\/TBK1 inhibitor to repress NF\u2010\u03baB and IL\u201010 signalling"],"prefix":"10.1111","volume":"24","author":[{"given":"Matthew","family":"Carr","sequence":"first","affiliation":[{"name":"Leicester Cancer Research Centre and Ernest and Helen Scott Haematological Research Unit University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Mamand","sequence":"additional","affiliation":[{"name":"Leicester Cancer Research Centre and Ernest and Helen Scott Haematological Research Unit University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn L.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Domainex Ltd., Chesterford Research Park Saffron Walden UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Perrior","sequence":"additional","affiliation":[{"name":"Domainex Ltd., Chesterford Research Park Saffron Walden UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-0370","authenticated-orcid":false,"given":"Simon D.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Leicester Cancer Research Centre and Ernest and Helen Scott Haematological Research Unit University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801445"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.027"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0016-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-137372"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1861"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08638"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153629"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907511106"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09671"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-573188"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-111948"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.28.11.1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806491106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276246"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3937"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.12.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20864"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-867499"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02403"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80445-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.8.1357"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.23.6694"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2008.01.002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni921"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040520"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119296109"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603133200"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607018200"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2423"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.052"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.08.014"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32634-5"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9145-7_12"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2144\/03342mt01"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074250"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802885"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.05.024"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.57"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114981109"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(00)00024-X"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119137109"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136567"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715118115"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087734"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.6004"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2019.10.005"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3499"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13659"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388538"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15774","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15774","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T10:09:47Z","timestamp":1771409387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":51,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jcmm.15774"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15774","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"2020-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}