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We demonstrated by an animal model recapitulating the calcification of the above condition that adrenaline transmits the stress signal of brain injury to the calcifying tissues. We have also found that although the level of plasma pyrophosphate, the endogenous inhibitor of calcification, was normal in calcifying animals, it could not counteract the acute calcification. However, externally added pyrophosphate inhibited calcification even when it was administered after the complex injuries. Our finding suggests a potentially powerful clinical intervention of calcification triggered by polytrauma injuries which has no effective treatment.<\/jats:p>","DOI":"10.1111\/jcmm.15793","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T08:40:02Z","timestamp":1599208802000},"page":"11791-11799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pyrophosphate therapy prevents trauma\u2010induced calcification in the mouse model of neurogenic heterotopic ossification"],"prefix":"10.1111","volume":"24","author":[{"given":"Nat\u00e1lia","family":"T\u0151k\u00e9si","sequence":"first","affiliation":[{"name":"Institute of Enzymology Research Center for Natural Sciences Hungarian Academy of Sciences Centre of Excellence  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Koz\u00e1k","sequence":"additional","affiliation":[{"name":"Institute 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