{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:01:30Z","timestamp":1791388890449,"version":"4.3.3"},"reference-count":121,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017MC067"],"award-info":[{"award-number":["ZR2017MC067"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701208"],"award-info":[{"award-number":["31701208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870331"],"award-info":[{"award-number":["81870331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aortic dissection (AD) is the rupture of the aortic intima, causing the blood in the cavity to enter the middle of the arterial wall. Without urgent and proper treatment, the mortality rate increases to 50% within 48\u00a0hours. Most patients present with acute onset of symptoms, including sudden severe pain and complex and variable clinical manifestations, which can be easily misdiagnosed. Despite this, the molecular mechanisms underlying AD are still unknown. Recently, non\u2010coding RNAs have emerged as novel regulators of gene expression. Previous studies have proven that ncRNAs can regulate several cardiovascular diseases; therefore, their potential as clinical biomarkers and novel therapeutic targets for AD has aroused widespread interest. To date, several studies have reported that microRNAs are crucially involved in AD progression. Additionally, several long non\u2010coding RNAs and circular RNAs have been found to be differentially expressed in AD samples, suggesting their potential roles in vascular physiology and disease. In this review, we discuss the functions of ncRNAs in AD pathophysiology and highlight their potential as biomarkers and therapeutic targets for AD. Meanwhile, we present the animal models previously used for AD research, as well as the specific methods for constructing mouse or rat AD models.<\/jats:p>","DOI":"10.1111\/jcmm.15802","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T08:56:01Z","timestamp":1599209761000},"page":"11622-11637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Non\u2010coding RNAs in aortic dissection: From biomarkers to therapeutic targets"],"prefix":"10.1111","volume":"24","author":[{"given":"Mengdie","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Cardiology The Affiliated hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-1904","authenticated-orcid":false,"given":"Yanyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Basic Medicine Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Cardiac Ultrasound The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0925-2242","authenticated-orcid":false,"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine The Affiliated Hospital of Qingdao University Qingdao China"},{"name":"Department of Cardiac Ultrasound The Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10026"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000483"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu281"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61005-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"issue":"13","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1016\/S0021-9258(18)68776-9","article-title":"Ehlers\u2010Danlos syndrome type IV: a multi\u2010exon deletion in one of the two COL3A1 alleles affecting structure, stability, and processing of type III procollagen","volume":"263","author":"Superti\u2010Furga A","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1511"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_11_10_1","first-page":"w14489","article-title":"Acute aortic dissection: pathogenesis, risk factors and diagnosis","volume":"147","author":"Gawinecka J","year":"2017","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212655110"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1129"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"370","article-title":"Downregulation of miR143\/145 gene cluster expression promotes the aortic media degeneration process via the TGF\u2010\u03b21 signaling pathway","volume":"11","author":"Zhang M","year":"2019","journal-title":"Am J Transl Res"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113797"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2017.1344217"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.03.036"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12436"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.02.017"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.02.018"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.02.021"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.4.352"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000568"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.134.4.361"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.304936"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.05.088"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355253"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.05.084"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.008128"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2012"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00536"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.3.487"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.08.019"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0071-z"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.204"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1397"},{"issue":"10","key":"e_1_2_11_37_1","first-page":"1018","article-title":"Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries","volume":"112","author":"Glagov S","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305938101"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.280883"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2441"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170252"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313440"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35737"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0713-577"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13696-3"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13104-w"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.11.113"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219013"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016013"},{"issue":"5","key":"e_1_2_11_50_1","first-page":"406","article-title":"MicroRNAs expression in normal and dissected aortic tissue","volume":"40","author":"Hu Z\u2010Y","year":"2012","journal-title":"Zhonghua xin xue guan bing za zhi"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.22"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2016.09.016"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2010.01.032"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2017019494"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2017-0010"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-015-9551-7"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.332"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2013.833294"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw245"},{"issue":"4","key":"e_1_2_11_61_1","first-page":"511","article-title":"Smooth muscle cell phenotypic diversity between dissected and unaffected thoracic aortic media","volume":"54","author":"Zhang J","year":"2013","journal-title":"J Cardiovasc Surg"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.213900"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10034-012-0019-6"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310694"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-290"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4293"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-230870"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23028"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1566743"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.06.011"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1418"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.173898"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.027"},{"issue":"3","key":"e_1_2_11_74_1","first-page":"198","article-title":"Post\u2010transcriptional control of tropoelastin in aortic smooth muscle cells affects aortic dissection onset","volume":"41","author":"Qi Y\u2010F","year":"2018","journal-title":"Mol Cells"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.14.38"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17-00027"},{"issue":"10","key":"e_1_2_11_77_1","first-page":"1136","article-title":"Expression of miR\u2010146b in peripheral blood serum and aortic tissues in patients with acute type Stanford A aortic dissection and its clinical significance","volume":"42","author":"Li J","year":"2017","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2009.08.007"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605298103"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.08.079"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna3030022"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150088"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22843"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.08.046"},{"issue":"3","key":"e_1_2_11_85_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0021-9258(19)75188-6","article-title":"Decreased lysyl oxidase activity in the aneurysm\u2010prone, mottled mouse","volume":"252","author":"Rowe DW","year":"1977","journal-title":"J Biol Chem"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307130"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08195"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38864"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7818"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00439.2003"},{"issue":"11","key":"e_1_2_11_91_1","first-page":"5138","article-title":"The diagnostic value of microRNA\u20104787\u20105p and microRNA\u20104306 in patients with acute aortic dissection","volume":"9","author":"Wang L","year":"2017","journal-title":"Am J Transl Res"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05654"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(200006)28:2<133::AID-GCC1>3.0.CO;2-K"},{"issue":"8","key":"e_1_2_11_94_1","first-page":"1029","article-title":"Upregulation of the high mobility group AT\u2010hook 2 gene in acute aortic dissection is potentially associated with endothelial\u2010mesenchymal transition","volume":"26","author":"Belge G","year":"2011","journal-title":"Histol Histopathol"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.19-00184"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.028"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.012"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488834"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160511229"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20238"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00500.2011"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.243121"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328317a730"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.2310\/6670.2008.00087"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500058102"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.6"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.232"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190156"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16448"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120479"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.135350"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.348"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178538"},{"issue":"3","key":"e_1_2_11_114_1","first-page":"3167","article-title":"LncRNA and mRNA interaction study based on transcriptome profiles reveals potential core genes in the pathogenesis of human thoracic aortic dissection","volume":"18","author":"Li Y","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11928"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.114"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.01.010"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306319"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12429"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18998"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401533"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11068-1"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:22:49Z","timestamp":1693862569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,4]]},"references-count":121,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jcmm.15802"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15802","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,4]]},"assertion":[{"value":"2020-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}