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Synovial inflammation is promoted through the infiltration of mononuclear immune cells, dominated by CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, macrophages and dendritic cells (DCs), together with fibroblast\u2010like synoviocytes (FLS), into the synovial compartment. Berberine is a bioactive isoquinoline alkaloid compound showing various pharmacological properties that are mainly attributed to immunomodulatory and anti\u2010inflammatory effects. Several lines of experimental study have recently investigated the therapeutic potential of berberine and its underlying mechanisms in treating RA condition. The present review aimed to clarify determinant cellular and molecular targets of berberine in RA and found that berberine through modulating several signalling pathways involved in the joint inflammation, including PI3K\/Akt, Wnt1\/\u03b2\u2010catenin, AMPK\/lipogenesis and LPA\/LPA\n                    <jats:sub>1<\/jats:sub>\n                    \/ERK\/p38 MAPK can inhibit inflammatory proliferation of FLS cells, suppress DC activation and modulate Th17\/Treg balance and thus prevent cartilage and bone destruction. Importantly, these molecular targets may explore new therapeutic targets for RA treatment.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15803","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T22:11:23Z","timestamp":1600899083000},"page":"12234-12245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management"],"prefix":"10.1111","volume":"24","author":[{"given":"Peng","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Stomatology Clinical Department of Aerospace City Northern Beijing Medical District Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Stomatology The 7th Medical Center Chinese PLA General Hospital Beijing China"},{"name":"Outpatient Department of PLA Macao Garrison Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Stomatology The 7th Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010hua","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Oral Diseases &amp; State Key Laboratory of Military Stomatology &amp; Shaanxi Key Laboratory of Oral Diseases Department of Prosthodontics School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-1083","authenticated-orcid":false,"given":"Amir Abbas","family":"Momtazi\u2010Borojeni","sequence":"additional","affiliation":[{"name":"Halal Research center of IRI FDA Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.190"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2050"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215582"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63016-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/berh.2001.0195"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.05.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216243"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23512"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2020_42"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.05.068"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-3-319-41334-1_2","volume-title":"Berberine and its role in chronic disease. 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