{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:27:04Z","timestamp":1772249224306,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51672030"],"award-info":[{"award-number":["51672030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity is a significant risk factor for atrial fibrillation (AF), which is the most common sustained arrhythmia with increased mortality and morbidity. High\u2010fat diet (HFD)\u2010induced obesity is associated with the activation of endoplasmic reticulum stress (ERS). However, the role of ERS in HFD\u2010induced AF remains elusive. Human atrium samples were examined for the ERS activation test. C57BL\/6J mice were divided into four groups, including the control group, the HFD group, the 4\u2010phenylbutyric acid (4\u2010PBA) group, and the HFD\u00a0+\u00a04\u2010PBA group. At the age of 4\u00a0weeks, the HFD group and the HFD\u00a0+\u00a04\u2010PBA group were given HFD to construct the obesity model, while the other two groups were given a normal diet (ND). Transesophageal programmed electrical stimulation was conducted to evaluate the AF inducibility and duration. Atrial fibrosis and ERS activation were also investigated.We found that CHOP and GRP\u201078 protein were significantly higher in overweight patients than the controls (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). AF inducibility and duration of the HFD group were significantly higher than the other groups (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), while there was no difference between those groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). The mice of the HFD group had significantly higher collagen volume fraction (CVF%) than the other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). ERS marker protein of GRP78, p\u2010PERK, ATF6 and CHOP protein expression level was increased in the HFD group, which were significantly mitigated in the HFD\u00a0+\u00a04\u2010PBA group. In summary, HFD\u2010induced ERS activation facilitates atrial fibrosis and AF. The inhibition of ERS might alleviate atrial fibrosis and reduce the incidence of AF\u2010associated obesity.<\/jats:p>","DOI":"10.1111\/jcmm.15816","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T04:55:07Z","timestamp":1604292907000},"page":"13660-13668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Inhibition of endoplasmic reticulum stress prevents high\u2010fat diet mediated atrial fibrosis and fibrillation"],"prefix":"10.1111","volume":"24","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Practice\/VIP Medical Service Beijing Hospital National Center of Gerontology Beijing China"},{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Practice\/VIP Medical Service Beijing Hospital National Center of Gerontology Beijing China"},{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of General Practice\/VIP Medical Service Beijing Hospital National Center of Gerontology Beijing China"},{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Practice\/VIP Medical Service Beijing Hospital National Center of Gerontology Beijing China"},{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deping","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"},{"name":"Department of Cardiology Beijing Hospital National Center of Gerontology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5724-6296","authenticated-orcid":false,"given":"Suyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of General Practice\/VIP Medical Service Beijing Hospital National Center of Gerontology Beijing China"},{"name":"Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.309732"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.064"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv486"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0604-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104649"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_11"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25098"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.09.025"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0634-1"},{"key":"e_1_2_9_11_1","first-page":"185","article-title":"Effect of oxidative stress on myocardial apoptosis, endoplasmic reticulum stress and apoptosis factor in suckling mouse atria myocardium","volume":"2","author":"Long J","year":"2017","journal-title":"Basic Res Cardiol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2522-3_15"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1547"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i2.56"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020160030000001"},{"issue":"10","key":"e_1_2_9_18_1","article-title":"Endoplasmic reticulum stress is associated with autophagy and cardiomyocyte remodeling in experimental and human atrial fibrillation","volume":"6","author":"Wiersma M","year":"2017","journal-title":"J Cell Physiol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13200"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.038"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490077"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.006040","article-title":"Interleukin 10 treatment ameliorates high\u2010fat diet\u2010induced inflammatory atrial remodeling and fibrillation","volume":"5","author":"Kondo H","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2982"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2015.05.004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.11.034"},{"key":"e_1_2_9_26_1","first-page":"1","article-title":"Heme Oxygenase\u20101 reduces sepsis\u2010induced endoplasmic reticulum stress and acute lung injury","volume":"2018","author":"Chen X","year":"2018","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00102.2018"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12561"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:01:59Z","timestamp":1705060919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":27,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/jcmm.15816"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15816","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"2020-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}