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We postulated that multiple mRNAs could combine into a model to improve risk stratification and helping clinicians make treatment decisions. In this study, the gene expression profiles were downloaded from the Gene Expression Omnibus (GEO) database. Weighted gene co\u2010expression network analysis (WGCNA) was used to screening genes in selected module which most closely related to PTCLs, and then built a mRNA signature using a LASSO Cox regression model and validated the prognostic accuracy of it. Finally, a nomogram was constructed and the performance was assessed. A total of 799 WGCNA\u2010selected mRNAs in black module were identified, and a mRNA signature which based on DOCK2, GSTM1, H2AFY, KCNAB2, LAPTM5 and SYK for PTCLs was developed. Significantly statistical difference can be seen in overall survival of PTCLs between low\u2010risk group and high\u2010risk group (training set:hazard ratio [HR] 4.3, 95% CI 2.4\u20107.4, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001; internal testing set:hazard ratio [HR] 2.4, 95% CI 1.2\u20104.8, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01; external testing set:hazard ratio [HR] 2.3, 95% CI 1.10\u20104.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Furthermore, multivariate regression demonstrated that the signature was an independently prognostic factor. Moreover, the nomogram which combined the mRNA signature and multiple clinical factors suggesting that predicted survival probability agreed well with the actual survival probability. The signature is a reliable prognostic tool for patients with PTCLs, and it has the potential for clinicians to implement personalized therapeutic regimen for patients with PTCLs.<\/jats:p>","DOI":"10.1111\/jcmm.15851","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T23:37:32Z","timestamp":1606865852000},"page":"84-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic and predictive value of a mRNA signature in peripheral T\u2010cell lymphomas: A mRNA expression analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Jiannan","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Oncology Nanping First Hospital Affiliated to Fujian Medical University Nanping 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