{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:20:42Z","timestamp":1792531242241,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573031"],"award-info":[{"award-number":["81573031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is a refractory disfiguring skin disease. However, the aetiology and pathogenesis of vitiligo have not been fully defined. Previous studies have shown that exosomes from normal human keratinocytes improve melanogenesis by up\u2010regulating the expression of melanogenesis\u2010related proteins. Several microRNAs (miRNAs) have been demonstrated to be effective in modulating melanogenesis via exosomes. In the present study, it was found that the effect of exosomes derived from keratinocytes in vitiligo lesions in regulating melanin synthesis is weakened. Furthermore, miR\u2010200c was detected to be significantly down\u2010regulated in exosomes from keratinocytes in vitiligo lesions. In addition, miR\u2010200c enhanced the expression of melanogenesis\u2010related genes via suppressing SOX1 to activate \u03b2\u2010catenin. In conclusion, our study revealed that the effect of exosomes secreted by keratinocytes in vitiligo lesions exhibited a weaker capacity in promoting melanogenesis of melanocytes. Moreover, the expression of miR\u2010200c, which mediates melanogenesis in exosomes secreted by keratinocytes in vitiligo lesions, is down\u2010regulated, which may be one of the pathogenesis in vitiligo. Therefore, keratinocyte\u2010derived exosomal miR\u2010200c may be a potential target for the treatment of vitiligo.<\/jats:p>","DOI":"10.1111\/jcmm.15864","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T07:52:33Z","timestamp":1601452353000},"page":"12164-12175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Down\u2010regulation of exosomal miR\u2010200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis"],"prefix":"10.1111","volume":"24","author":[{"given":"Chaoshuai","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-4833","authenticated-orcid":false,"given":"Weimin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.117"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.01.028"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12512500"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(91)90070-B"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.011973"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09064.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.09.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1092"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.5.457"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00898.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23667.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10253-w"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200302000-00004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21945"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.02.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2712"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8506"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15202"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.478"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.02.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010313"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-257"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9827519"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2019.2075"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-03230"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000708R"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25387"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201700058"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12592"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/1831751a0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.07.009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1420-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1490-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.568"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1398-2"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.01.023"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103036"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0706-z"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.05.016"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20180684"},{"issue":"1","key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"17021","DOI":"10.1038\/celldisc.2017.21","article-title":"miRNA\u2010200c\u20103p is crucial in acute respiratory distress syndrome","volume":"3","author":"Liu Q","year":"2017","journal-title":"Cell Discov"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8061901"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.06.016"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003816200"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi442"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.05.007"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00711.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111165"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02299-05"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.15864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15864","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:19:22Z","timestamp":1693862362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,11]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jcmm.15864"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15864","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,11]]},"assertion":[{"value":"2020-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}