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Here, we performed an in\u2010depth analysis of our previously published Chinese GWAS cohort study with replication in an extra dbGaP case\u2010parent trios and another in\u2010house Nanjing cohort, and finally identified five novel significant association signals (rs11119445: 3\u2019 of <jats:italic>SERTAD4<\/jats:italic>, <jats:italic>P<\/jats:italic>\u00a0=\u00a06.44\u00a0\u00d7\u00a010<jats:sup>\u221214<\/jats:sup>; rs227227 and rs12561877: intron of <jats:italic>SYT14<\/jats:italic>, <jats:italic>P<\/jats:italic>\u00a0=\u00a05.02\u00a0\u00d7\u00a010<jats:sup>\u221213<\/jats:sup> and 2.80\u00a0\u00d7\u00a010<jats:sup>\u221211<\/jats:sup>, respectively; rs643118: intron of <jats:italic>TRAF3IP3<\/jats:italic>, <jats:italic>P<\/jats:italic>\u00a0=\u00a04.45\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>; rs2095293: intron of <jats:italic>NR6A1<\/jats:italic>, <jats:italic>P<\/jats:italic>\u00a0=\u00a02.98\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>). The mean (standard deviation) of the weighted genetic risk score (wGRS) from these SNPs was 1.83 (0.65) for NSCL\/P cases and 1.58 (0.68) for controls, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a02.67\u00a0\u00d7\u00a010<jats:sup>\u221216<\/jats:sup>). Rs643118 was identified as a shared susceptible factor of NSCL\/P among Asians and Europeans, while rs227227 may contribute to the risk of NSCL\/P as well as NSCPO. In addition, sertad4 knockdown zebrafish models resulted in down\u2010regulation of sox2 and caused oedema around the heart and mandibular deficiency, compared with control embryos. Taken together, this study has improved our understanding of the genetic susceptibility to NSCL\/P and provided further clues to its aetiology in the Chinese population.<\/jats:p>","DOI":"10.1111\/jcmm.15878","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T19:39:36Z","timestamp":1603827576000},"page":"13669-13678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Identification of novel susceptibility loci for non\u2010syndromic cleft lip with or without cleft palate"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-5626","authenticated-orcid":false,"given":"Lan","family":"Ma","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University  Nanjing China"},{"name":"Department of Environmental Genomics Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment Collaborative 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