{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:47:13Z","timestamp":1791218833816,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701960"],"award-info":[{"award-number":["81701960"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770491"],"award-info":[{"award-number":["81770491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver steatosis is associated with increased ischaemia reperfusion (I\/R) injury. Our previous studies have shown that irisin, an exercise\u2010induced hormone, mitigates I\/R injury via binding to \u03b1V\u03b25 integrin. However, the effect of irisin on I\/R injury in steatotic liver remains unknown. Kindlin\u20102 directly interacts with \u03b2 integrin. We therefore suggest that irisin protects against I\/R injury in steatotic liver via a kindlin\u20102 dependent mechanism. To study this, hepatic steatosis was induced in male adult mice by feeding them with a 60% high\u2010fat diet (HFD). At 12\u00a0weeks after HFD feeding, the mice were subjected to liver ischaemia by occluding partial (70%) hepatic arterial\/portal venous blood for 60\u00a0minutes, which was followed by 24\u00a0hours reperfusion. Our results showed HFD exaggerated I\/R\u2010induced liver injury. Irisin (250\u00a0\u03bcg\/kg) administration at the beginning of reperfusion attenuated liver injury, improved mitochondrial function, and reduced oxidative and endoplasmic reticulum stress in HFD\u2010fed mice. However, kindlin\u20102 inhibition by RNAi eliminated irisin's direct effects on cultured hepatocytes. In conclusion, irisin attenuates I\/R injury in steatotic liver via a kindlin\u20102 dependent mechanism.<\/jats:p>","DOI":"10.1111\/jcmm.15910","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T01:52:16Z","timestamp":1600653136000},"page":"13081-13092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Involvement of kindlin\u20102 in irisin\u2019s protection against ischaemia reperfusion\u2010induced liver injury in high\u2010fat diet\u2010fed mice"],"prefix":"10.1111","volume":"24","author":[{"given":"Jia","family":"Zhang","sequence":"first","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Ren","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Bi","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhou","family":"Wang","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Wei","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Mou","sequence":"additional","affiliation":[{"name":"Zonglian College Xi\u2019an Jiaotong University Health Science Center Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lv","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0993-4531","authenticated-orcid":false,"given":"Rongqian","family":"Wu","sequence":"additional","affiliation":[{"name":"National Local Joint Engineering Research Center for Precision Surgery &amp; Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering First Affiliated Hospital of Xi\u2019an Jiaotong University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28524"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30848"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30702"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5812\/atr.12501"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7195"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5486"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10777"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000608"},{"issue":"418","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aao6298","article-title":"Irisin protects mitochondria function during pulmonary ischemia\/reperfusion injury","volume":"9","author":"Chen K","year":"2017","journal-title":"Sci Transl Med"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.05.011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25857"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.12.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.09.054"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109452"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7857082"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.10.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14811"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.202"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703064114"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.025"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.08.032"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000857"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25935"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000251747.80025.b7"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.032"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.01.020"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000225113.88433.cf"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.004"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.07.017"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12933"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6776"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010015"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2013.811721"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206777947614"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20504"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1476-1"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.04.030"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.1221688","article-title":"Irisin, light my fire","volume":"336","author":"Medicine KDP","year":"2012","journal-title":"Science"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.221"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165705"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.05.036"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.225"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4729"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941930390205773"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.29"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.10.004"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030327"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.008"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2010.10.012"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-519868"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.161190"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-010-0202-3"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.06.050"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25223"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-0025-0"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016091021"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8531"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.910059"},{"issue":"8","key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCHEARTFAILURE.116.003129","article-title":"Postnatal loss of kindlin\u20102 leads to progressive heart failure","volume":"9","author":"Zhang Z","year":"2016","journal-title":"Circ Heart Fail"},{"issue":"13","key":"e_1_2_9_62_1","first-page":"1","article-title":"Lipoatrophy and metabolic disturbance in mice with adipose\u2010specific deletion of kindlin\u20102","volume":"4","author":"Gao H","year":"2019","journal-title":"JCI Insight"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14000"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.05.013"},{"key":"e_1_2_9_65_1","first-page":"5339","article-title":"UV\u2010B\u2010induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome","volume":"25","author":"Maier K","year":"2016","journal-title":"Hum Mol Genet"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3AB0118-005R"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08772-3"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15910","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T14:42:00Z","timestamp":1693838520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,20]]},"references-count":66,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/jcmm.15910"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15910","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,20]]},"assertion":[{"value":"2020-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}