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Previous studies have noted the importance of myeloid\u2010derived suppressor cells (MDSC) in MS progression. However, it is still not known whether methylprednisolone could influence the ratio and function of MDSC during MS treatment. In the current study, we found an increased ratio of MDSC at the onset of EAE in mice model; but methylprednisolone pulse therapy (MPPT) did not alter the percentage and suppressive function of MDSC during disease attenuation. However, the percentage of G\u2010MDSC in PBMC significantly increased in patients with MS. Surprisingly, relapsing MS patients showed a significant increase in both M\u2010MDSC and G\u2010MDSC after MPPT. The disease remission positively correlated expansion of MDSC and expression of arginase\u20101. Additionally, MPPT reduced the expression of inhibitory glucocorticoid (GCs) receptor \u03b2 subunit on MDSC while elevating serum levels of immune regulatory S100A8\/A9 heterodimer. Thus, MDSC dynamics and function in mouse EAE differ from those in human MS during MPPT. Our study suggested that GCs treatment may help relieve the acute phase of MS by expanding MDSC through up\u2010regulating of GR signalling and S100A8\/A9 heterodimers.<\/jats:p>","DOI":"10.1111\/jcmm.15928","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T16:14:02Z","timestamp":1603469642000},"page":"13703-13714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Methylprednisolone alleviates multiple sclerosis by expanding myeloid\u2010derived suppressor cells via glucocorticoid receptor \u03b2 and S100A8\/9 up\u2010regulation"],"prefix":"10.1111","volume":"24","author":[{"given":"Zhongkun","family":"Wang","sequence":"first","affiliation":[{"name":"Central Laboratory The First Hospital of Jilin University Changchun China"},{"name":"Key Laboratory of Organ Regeneration and Transplantation Ministry of Education Changchun China"},{"name":"Vasculocardiology Department The Second 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