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As an essential environmental cue that maintains glioma stem cells, hypoxia is considered the cause of tumour resistance to chemotherapy and radiation. Growing evidence shows that immunotherapy focusing on the tumour microenvironment is an effective treatment for GBM; however, the current clinicopathological features cannot predict the response to immunotherapy and provide accurate guidance for immunotherapy. Based on the ESTIMATE algorithm, GBM cases of The Cancer Genome Atlas (TCGA) data set were classified into high\u2010 and low\u2010immune\/stromal score groups, and a four\u2010gene tumour environment\u2010related model was constructed. This model exhibited good efficiency at forecasting short\u2010 and long\u2010term prognosis and could also act as an independent prognostic biomarker. Additionally, this model and four of its genes (<jats:italic>CLECL5A, SERPING1, CHI3L1<\/jats:italic> and <jats:italic>C1R<\/jats:italic>) were found to be associated with immune cell infiltration, and further study demonstrated that these four genes might drive the hypoxic phenotype of perinecrotic GBM, which affects hypoxia\u2010induced glioma stemness. Therefore, these might be important candidates for immunotherapy of GBM and deserve further exploration.<\/jats:p>","DOI":"10.1111\/jcmm.15939","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T09:44:29Z","timestamp":1601718269000},"page":"13235-13247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic value and immune cell infiltration of hypoxic phenotype\u2010related gene signatures in glioblastoma microenvironment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-2789","authenticated-orcid":false,"given":"Kai","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiangya 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