{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:01:01Z","timestamp":1783947661018,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["C2020405008"],"award-info":[{"award-number":["C2020405008"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myocardial infarction (MI) results in cardiomyocyte death and ultimately leads to heart failure. Pyroptosis is a type of the inflammatory programmed cell death that has been found in various diseased tissues. However, the role of pyroptosis in MI heart remains unknown. Here, we showed that CXADR\u2010like membrane protein (CLMP) was involved in pyroptosis in the mouse MI heart. Our data showed that CLMP was strongly expressed in fibroblasts of the infarcted mouse hearts. The <jats:italic>Clmp<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice showed more serious myocardial fibrosis and ventricular dysfunction post\u2010MI than wild\u2010type (<jats:italic>Clmp<\/jats:italic><jats:sup>+\/+<\/jats:sup>) mice, indicating a protective effect of the fibroblast\u2010expressed CLMP against MI\u2010induced heart damage. Transcriptome analyses by RNA sequencing indicated that <jats:italic>Il\u20101\u03b2<\/jats:italic> mRNA was significantly increased in the MI heart of <jats:italic>Clmp<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mouse, which indicated a more serious inflammatory response. Meanwhile, cleaved caspase\u20101 and Gasdermin D were significantly increased in the <jats:italic>Clmp<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> MI heart, which demonstrated enhanced pyroptosis in the <jats:italic>Clmp<\/jats:italic> knockdown heart. Further analysis revealed that the pyroptosis mainly occurred in cardiac fibroblasts (CFs). Compared to wild\u2010type fibroblasts, <jats:italic>Clmp<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> CFs showed more serious pyroptosis and inflammatory after LPS plus nigericin treatment. Collectively, our results indicate that CLMP participates in the pyroptotic and inflammatory response of CFs in MI heart. We have provided a novel pyroptotic insight into the ischaemic heart, which might hold substantial potential for the treatment of MI.<\/jats:p>","DOI":"10.1111\/jcmm.15955","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T07:10:40Z","timestamp":1603264240000},"page":"13775-13788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["CXADR\u2010like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction"],"prefix":"10.1111","volume":"24","author":[{"given":"Xinglong","family":"Han","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery of the First Affiliated Hospital &amp; Institute for Cardiovascular Science State Key Laboratory of Radiation Medicine and Protection Medical College Soochow University Suzhou 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