{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:27:37Z","timestamp":1792506457122,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900216"],"award-info":[{"award-number":["81900216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to determine the efficacy of Zinc finger protein ZBTB20 in treatment of post\u2010infarction cardiac remodelling. For this purpose, left anterior descending (LAD) ligation was operated on mice to induce myocardial infarction (MI) with sham control group as contrast and adeno\u2010associated virus (AAV9) system was used to deliver ZBTB20 to mouse heart by myocardial injection with vehicle\u2010injected control group as contrast two weeks before MI surgery. Then four weeks after MI, vehicle\u2010treated mice with left ventricular (LV) remodelling underwent deterioration of cardiac function, with symptoms of hypertrophy, interstitial fibrosis, inflammation and apoptosis. The vehicle\u2010injected mice also showed increase of infarct size and decrease of survival rate. Meanwhile, the ZBTB20\u2010overexpressed mice displayed improvement after MI. Moreover, the anti\u2010apoptosis effect of ZBTB20 was further confirmed in H9c2 cells subjected to hypoxia in vitro. Further study suggested that ZBTB20 exerts cardioprotection by inhibiting tumour necrosis factor \u03b1\/apoptosis signal\u2010regulating kinase 1 (ASK1)\/c\u2010Jun N\u2010terminal kinase 1\/2 (JNK1\/2) signalling, which was confirmed by shRNA\u2010JNK adenoviruses transfection or a JNK activator in vitro as well as ASK1 overexpression in vivo. In summary, our data suggest that ZBTB20 could alleviate cardiac remodelling post\u2010MI. Thus, administration of ZBTB20 can be considered as a promising treatment strategy for heart failure post\u2010MI.<\/jats:p><jats:p>Significance Statement: ZBTB20 could alleviate cardiac remodelling post\u2010MI via inhibition of ASK1\/JNK1\/2 signalling.<\/jats:p>","DOI":"10.1111\/jcmm.15961","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T11:48:09Z","timestamp":1602848889000},"page":"13383-13396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Zinc Finger Protein ZBTB20 protects against cardiac remodelling post\u2010myocardial infarction via ROS\u2010TNF\u03b1\/ASK1\/JNK pathway regulation"],"prefix":"10.1111","volume":"24","author":[{"given":"Fangfang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Xuzhou Medical University Xuzhou China"},{"name":"Institute of Cardiovascular Disease Research Xuzhou Medical 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