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Our results revealed that FA pre\u2010treatment for 24\u00a0hours can reverse cell loss of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced ARPE\u201019 cells via the promotion of cell proliferation and prevention of apoptosis, as evidenced by 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine (EdU) incorporation and terminal deoxynucleotidyl transferase\u2010mediated dUTP nick end\u2010labelling (TUNEL) assay, respectively. Moreover, the addition of FA (5\u00a0mM) can decrease Bax and cleaved caspase\u20103 protein expression, but increase Bcl\u20102 protein expression in ARPE\u201019 cells. Furthermore, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced oxidative stress in ARPE\u201019 cells was significantly alleviated by FA, illustrated by reduced levels of ROS and MDA. In addition, the attenuated antioxidant enzymes activities of (SOD, CAT and GPX) and GSH level were reversed almost to the normal base level by the pre\u2010addition of FA for 24\u00a0hours. In all assays, FA itself did not exert any effect on the change of the above parameters. These novel findings indicated that FA effectively protected human ARPE\u201019 cells from H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010induced oxidative damage through its pro\u2010proliferation, anti\u2010apoptosis and antioxidant activity, suggesting that FA has a therapeutic potential in the prevention and treatment of AMD.<\/jats:p>","DOI":"10.1111\/jcmm.15970","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T15:38:58Z","timestamp":1603208338000},"page":"13454-13462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Ferulic acid (FA) protects human retinal pigment epithelial cells from H<sub>2<\/sub>O<sub>2<\/sub>\u2010induced oxidative injuries"],"prefix":"10.1111","volume":"24","author":[{"given":"Kunpeng","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Ophthalmology the First Affiliated Hospital of Zhengzhou University Henan Province Eye 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