{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:50:47Z","timestamp":1786971047462,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Emerging studies suggested that lncRNAs play a crucial molecular role in cancer development and progression. LncRNA LUCAT1 has been proved as oncogenic molecular in lung cancer, glioma, osteosarcoma, renal carcinoma and oesophageal squamous cell carcinoma. However, its roles and function mechanisms in tongue squamous cell carcinoma (TSCC) are still unknown. We showed that the expression of LUCAT1 was up\u2010regulated in the TSCC cells and tissues and the higher LUCAT1 expression was associated with the poor overall survival (OS). Knockdown expression of LUCAT1 suppressed TSCC cell proliferation, cycle and migration. In addition, we demonstrated that miR\u2010375 overexpression inhibited the luciferase activity of LUCAT1 wild\u2010type and knockdown LUCAT1 promoted the miR\u2010375 expression in TSCC cell. Furthermore, we indicated that miR\u2010375 expression was down\u2010regulated in the TSCC cell lines and tissues and the lower expression of miR\u2010375 was associated with poor OS. The expression of miR\u2010375 was inversely correlated with LUCAT1 expression in the TSCC tissues. Knockdown LUCAT1 promoted TSCC cell proliferation, cell cycle and migration partly through regulating miR\u2010375 expression. In summary, this study suggested the tumorigenic effect of lncRNA LUCAT1 in TSCC cells by targeting miR\u2010375 expression.<\/jats:p>","DOI":"10.1111\/jcmm.15982","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T01:40:16Z","timestamp":1617154816000},"page":"4543-4550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["LUCAT1 as an oncogene in tongue squamous cell carcinoma by targeting miR\u2010375 expression"],"prefix":"10.1111","volume":"25","author":[{"given":"Kai","family":"Zhang","sequence":"first","affiliation":[{"name":"Center of Stomatology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endodontics Jinan Stomatological Hospital Shandong 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