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Recently, we developed a novel drug delivery model using protein transduction domains (PTD) overcoming limitation of soluble recombinant proteins, including bone morphogenetic protein\u20107 (BMP\u20107). This study aims at evaluating the therapeutic effects of PTD\u2010BMP\u20107 consisted of PTD and full\u2010length BMP\u20107 on epithelial\u2010mesenchymal transition (EMT)\u2010related fibrosis. Human peritoneal mesothelial cells (HPMCs) were then treated with TGF\u2010\u03b21 or TGF\u2010\u03b21\u00a0+\u00a0PTD\u2010BMP\u20107. Peritoneal dialysis (PD) catheters were inserted into Sprague\u2010Dawley rats, and these rats were infused intra\u2010peritoneally with saline, peritoneal dialysis fluid (PDF) or PDF\u00a0+\u00a0PTD\u2010BMP\u20107. In vitro, TGF\u2010\u03b21 treatment significantly increased fibronectin, type I collagen, \u03b1\u2010SMA and Snail expression, while reducing E\u2010cadherin expression in HPMCs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). PTD\u2010BMP\u20107 treatment ameliorated TGF\u2010\u03b21\u2010induced fibronectin, type I collagen, \u03b1\u2010SMA and Snail expression, and restored E\u2010cadherin expression in HPMCs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). In vivo, the expressions of EMT\u2010related molecules and the thickness of the sub\u2010mesothelial layer were significantly increased in the peritoneum of rats treated with PDF, and these changes were significantly abrogated by the intra\u2010peritoneal administration of PTD\u2010BMP\u20107. PTD\u2010BMP\u20107 treatment significantly inhibited the progression of established PD fibrosis. These findings suggest that PTD\u2010BMP\u20107, as a prodrug of BMP\u20107, can be an effective therapeutic agent for peritoneal fibrosis in PD patients.<\/jats:p>","DOI":"10.1111\/jcmm.15992","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T16:18:17Z","timestamp":1603210697000},"page":"13507-13522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Newly designed Protein Transduction Domain (PTD)\u2010mediated BMP\u20107 is a potential therapeutic for peritoneal fibrosis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-1156","authenticated-orcid":false,"given":"Seonghun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Oral Cancer Research Institute Yonsei University College of Dentistry  Seoul 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