{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:22:21Z","timestamp":1777098141729,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000305","name":"National Eye Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The leading cause of central vision loss, age\u2010related macular degeneration (AMD), is a degenerative disorder characterized by atrophy of retinal pigment epithelium (RPE) and photoreceptors. For 15% of cases, neovascularization occurs, leading to acute vision loss if left untreated. For the remaining patients, there are currently no treatment options and preventing progressive RPE atrophy remains the main therapeutic goal. Previously, we have shown treatment with interleukin\u201033 can reduce choroidal neovascularization and attenuate tissue remodelling. Here, we investigate IL\u201033 delivery in aged, high\u2010fat diet (HFD) fed mice on a wildtype and complement factor H heterozygous knockout background. We characterize the non\u2010toxic effect following intravitreal injection of IL\u201033 and further demonstrate protective effects against RPE cell death with evidence of maintaining metabolic retinal homeostasis of <jats:italic>Cfh<\/jats:italic>+\/\u2212~HFD mice. Our results further support the potential utility of IL\u201033 to prevent AMD progression.<\/jats:p>","DOI":"10.1111\/jcmm.16000","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T15:08:34Z","timestamp":1603206514000},"page":"13546-13550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment with interleukin\u201033 is non\u2010toxic and protects retinal pigment epithelium in an ageing model of outer retinal degeneration"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0048-8838","authenticated-orcid":false,"given":"Alison J.","family":"Clare","sequence":"first","affiliation":[{"name":"Academic Unit of Ophthalmology Translational Health Sciences University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Copland","sequence":"additional","affiliation":[{"name":"Academic Unit of 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Ophthalmology  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Dick","sequence":"additional","affiliation":[{"name":"Academic Unit of Ophthalmology Translational Health Sciences University of Bristol  Bristol UK"},{"name":"School of Cellular and Molecular Medicine University of Bristol  Bristol UK"},{"name":"UCL Institute of Ophthalmology  London UK"},{"name":"NIHR Biomedical Research Centre of Ophthalmology Moorfields Eye Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Theodoropoulou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Cheltenham General Hospital  Cheltenham 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