{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:22:01Z","timestamp":1784305321066,"version":"3.55.0"},"reference-count":96,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ19H020007"],"award-info":[{"award-number":["LQ19H020007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vascular calcification refers to the pathological deposition of calcium and phosphate minerals into the vasculature. It is prevalent in atherosclerosis, ageing, type 2 diabetes mellitus and chronic kidney disease, thus, increasing morbidity and mortality from these conditions. Vascular calcification shares similar mechanisms with bone mineralization, with smooth muscle cells playing a critical role in both processes. In the last decade, a variety of microRNAs have been identified as key regulators for the differentiation, phenotypic switch, proliferation, apoptosis, cytokine production and matrix deposition in vascular smooth muscle cells during vascular calcification. Therefore, this review mainly discusses the roles of microRNAs in the pathophysiological mechanisms of vascular calcification in smooth muscle cells and describes several interventions against vascular calcification by regulating microRNAs. As the exact mechanisms of calcification remain not fully elucidated, having a better understanding of microRNA involvement in vascular calcification may give impetus to development of novel therapeutics for the control and treatment of vascular calcification.<\/jats:p>","DOI":"10.1111\/jcmm.16005","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T14:49:14Z","timestamp":1603378154000},"page":"13564-13572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["MicroRNAs are critical in regulating smooth muscle cell mineralization and apoptosis during vascular calcification"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-6167","authenticated-orcid":false,"given":"Shan\u2010shan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology Zhejiang Provincial Key Lab of Cardiovascular Disease Diagnosis and Treatment Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhejiang Provincial Key Lab of Cardiovascular Disease Diagnosis and Treatment Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhejiang Provincial Key Lab of Cardiovascular Disease Diagnosis and Treatment Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302070"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743161"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302642"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.12.017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1640-z"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000133041.27682.A2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35008121"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2014.10.021"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164437"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.12.022"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.10.1842"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000059406.92165.31"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000249379.55535.21"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00820.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.390898"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2018.08.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.073"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.06.016"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000128955.83129.9C"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.01.025"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.4.589"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047807"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy140"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41101-8"},{"key":"e_1_2_6_28_1","first-page":"8361","article-title":"A novel RhoA\/ROCK\u2010CPI\u201017\u2010MEF2C signaling pathway regulates vascular smooth muscle cell gene expression","volume":"287","author":"Pagiatakis C","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.264473"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1957-3"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.09.024"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050520"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs258"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00320"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2236"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-012-0934-3"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3005"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/354517"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23106"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.292722"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.356"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv030"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.003905"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.05.011"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds129"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201201057"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.012"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2469-8"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101973"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505571"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6713606"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300206"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234914"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2003"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.225904"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.01.067"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.11.033"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12311"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.176099"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/624037"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc883"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.11.1055"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.915270"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.12.022"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311298"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0751"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.05.009"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-271254"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489203"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.47"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210410"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-014-0987-y"},{"key":"e_1_2_6_73_1","first-page":"1367","article-title":"MicroRNA\u201026a protects vascular smooth muscle cells against H2O2\u2010induced injury through activation of the PTEN\/AKT\/mTOR pathway","volume":"42","author":"Peng JL","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000016358.05294.8D"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806920200"},{"key":"e_1_2_6_76_1","first-page":"2691514","article-title":"MicroRNA\u201025 protects smooth muscle cells against corticosterone\u2010induced apoptosis","volume":"2019","author":"Zhang B","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008955200"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161024353"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0371"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101758"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0141"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2181"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.062"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00773.x"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12631"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-019-00669-0"},{"key":"e_1_2_6_87_1","first-page":"2297","article-title":"Reduction of atherosclerotic lesions in rabbits treated with etoposide associated with cholesterol\u2010rich nanoemulsions","volume":"6","author":"Tavares ER","year":"2011","journal-title":"Int J Nanomed"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311546"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.10.198"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00759-06"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfu139"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.09.068"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800747"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09174-1"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28130"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.85"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.02.007"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.16005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.16005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:02:33Z","timestamp":1705060953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.16005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":96,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/jcmm.16005"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.16005","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"assertion":[{"value":"2020-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}