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Exosomes are nanosized particles with biological capacities. Here, we aimed to study the effects of T cell\u2013derived exosomes (T\u2010exos) on the pathogenesis of OLP and its mechanism. T\u2010exos were incubated with Jurkat cells for 48\u00a0hours, and 26 cytokines in the supernatant were measured by luminex assay. The expression of macrophage inflammatory protein (MIP)\u20101\u03b1\/\u03b2 was detected using immunohistochemistry and ELISA; that of CCR1\/3\/5 on peripheral T cells was determined by flow cytometry. Transwell assay was performed to investigate the chemotactic effect of MIP\u20101\u03b1\/\u03b2, and cells in the lower chambers were examinated by flow cytometry. As a result, OLP T\u2010exos elevated the production of MIP\u20101\u03b1\/\u03b2, which were highly expressed in OLP tissues and plasma. CCR1\/5 were markedly expressed on OLP peripheral T cells, and the majority of CCR1\/5<jats:sup>+<\/jats:sup> T cells were CD8<jats:sup>+<\/jats:sup> T cells. Besides, MIP\u20101\u03b1\/\u03b2 promoted the migration of OLP mononuclear\u00a0cells, while inhibiting CCR1\/5 significantly decreased the trafficking of mononuclear\u00a0cells, especially that of CD8<jats:sup>+<\/jats:sup> T cells. Conclusively, OLP T\u2010exos\u2010induced MIP\u20101\u03b1\/\u03b2 may drive the trafficking of CD8<jats:sup>+<\/jats:sup> T cells after binding with CCR1\/5 in OLP, contributing to the development of OLP.<\/jats:p>","DOI":"10.1111\/jcmm.16020","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T14:56:06Z","timestamp":1603810566000},"page":"14086-14098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["T cell\u2013derived exosomes induced macrophage inflammatory protein\u20101\u03b1\/\u03b2 drive the trafficking of CD8<sup>+<\/sup> T cells in oral lichen planus"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-6701","authenticated-orcid":false,"given":"Jing\u2010Ya","family":"Yang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral 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